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Hamburger Disease is caused by a specific Escherichia coli called E. coli O157:H7. In North America, this disease is the fourth most costly foodborne disease with over 30,000 cases estimated yearly. Approximately 10% of children infected with Hamburger Disease progress to a condition called Hemolytic Uremic Syndrome (HUS) which can cause kidney failure, neurological damage, and death.

The initial research and development of SYNSORB Pk was done by Dr. Glen D. Armstrong using technology developed by Dr. Raymond Lemieux at the University of Alberta.

References:

• Armstrong, G., Rowe, P. Orrbine, E., Lior, H., Goodyer, P., McLaine, P. and the CPKDRC SYNSORB-Pk Study Group. 1995. A phase 1 trial of SYNSORB-Pk in preventing hemolytic-uremic syndrome (HUS). ). J. Infect. Dis. 171:1042-1045
• P.C. Rowe, E. Orrbine, H. Lior, G.A. Wells, and P.N. McLaine, A prospective study of exposure to verotoxin-producing Escherichia coli among Canadian children with haemolytic uraemic syndrome. Epidemiol Infect 110:1-7(1993)
• Armstrong, G.D., Fodor, E., and R. Vanmaele. 1991. Investigation of shiga-like toxin binding to synthetic oligosaccharide sequences. J. Infect. Dis. 164:1160-67.

Should you have any further questions about the CPKDRC and its current projects, please contact Ms. Elaine Orrbine, Associate Director.