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Adrenal Insufficiency

Adrenal insufficiency related to critical illness is a serious condition characterized by an elevated heart rate, low blood pressure, and a lack of response to fluid and inotrope therapy. Adrenal insufficiency results from an inadequate level of cortisol (the body’s intrinsic corticosteroid) to deal with critical illness. Many clinicians believe that corticosteroids improve outcomes in such patients. However, the effectiveness and safety of steroid replacement therapy in this population remain to be demonstrated. The PICU research group is conducting a multi-stage research program to address this issue, with an end goal of developing evidence based guidelines to optimize the care provided to critically ill children.
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