Arthritis and Rheumatology

The pediatric rheumatology research team is focusing on the following areas of research:

Muscle function and muscle function deficits in rheumatic diseases
Ultrasound of the musculoskeletal system in children
Longitudinal studies on short and long-term outcomes in JIA
Psycho Social Outcomes in rheumatic diseases
Therapeutic trials of new medication
The links between exercise, physical activity and pathophysiology in JIA (LEAP study)
The overarching goal is to provide best possible treatment that has been properly evaluated, improve the diagnostic possibilities and ensure optimal outcomes in all relevant areas (physical and psychosocial) through research

Research Projects

Mitigating the Denosumab‑Induced Rebound Phenomenon with Alternating Short‑ and Long‑Acting Anti‑resorptive Therapy in a Young Boy with Severe OI Type V
03/03/2023
Toward Developing a Semiquantitative Whole Body-MRI Scoring for Juvenile Idiopathic Arthritis: Critical Appraisal of the State of the Art, Challenges, and Opportunities.
02/03/2020
SMAC mimetics and RIPK inhibitors as therapeutics for chronic inflammatory diseases
18/02/2020

This may benefit and guide the development of SMs or selective RIPK inhibitors as anti-inflammatory therapeutics for various chronic inflammatory conditions.
Prospective Determination of the Incidence and Risk Factors of New-Onset Uveitis in Juvenile Idiopathic Arthritis: The Research in Arthritis in Canadian Children Emphasizing Outcomes Cohort
01/11/2019

Identification of the incidence of juvenile idiopathic arthritis (JIA)-associated uveitis and its risk factors is essential to optimize early detection. Data from the Research in Arthritis in Canadian Children Emphasizing Outcomes inception cohort were used to estimate the annual incidence of new-onset uveitis following JIA diagnosis and to identify associated risk factors.
Understanding parent perceptions of healthy physical activity for their child with a chronic medical condition: A cross-sectional study
01/06/2019

Over one-third of parents reported having questions about physical activity for their child with a chronic medical condition, suggesting substantial uncertainty even among children reported as active. Presence of parent uncertainty is associated with parent reports of the child being unwell or a history of cardiac arrhythmia
Health-Related Quality of Life in an InceptionCohort of Children With Juvenile IdiopathicArthritis: A Longitudinal Analysis
02/01/2018

Improvement in HRQoL is slower than for disease activity, pain, and disability. Improvement of a mea- sure based on respondents’ preferences (HRQoML) is more rapid than that of a standardized measure (JAQQ). Higher disease activity at diagnosis heralds an unfavorable HRQoL trajectory.
The risk and nature of flares in juvenile idiopathic arthritis: results from the ReACCh-Out cohort
01/05/2015

In this real-practice JIA cohort, flares were frequent, usually involved a few swollen joints for an average of 6 months and 60% led to treatment intensification. Children with a severe disease course had an increased risk of flare.