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Collaborative Research

Type 1 Diabetes TrialNet (TrialNet) Studies:
TrialNet is an international network of researchers who are exploring ways to prevent, delay and reverse the progression of type 1 diabetes. Here at CHEO we partake in 3 TrialNet Studies:

1. The Natural History Study: is an international study which screens and observes relatives of people with type 1 diabetes to learn more about who develops diabetes and how.
2. The Oral Insulin Study: is an international study which tests whether a daily oral insulin capsule can prevent or delay the disease in at-risk relatives of people with type 1 diabetes. 
3. LIFT Study: is an international study which monitors the progress of children and youth who have developed type 1 diabetes.

MiTy Kids Study:
There is some evidence that children of mothers with type 2 diabetes have a higher than average chance of being overweight or obese as they get older, and having risk factors for heart disease.

MiTy Kids Study is a follow-up study to the MiTy Trial which will determine whether treatment with metformin during pregnancy in women with type 2 diabetes reduces the child’s risk of being overweight or obese, and reduce his/her risk of risk factors for heart disease.

TRIGR Study:

The cause of type 1 diabetes has been investigated for several decades. Strong evidence suggests that environmental factors increase the risk of diabetes in people who are genetically susceptible. If these environmental factors could be identified and eliminated, it should be possible to decrease the number of children who develop type 1 diabetes.


TRIGR was an international study testing whether hydrolyzed infant formula compared to cow's milk-based formula decreases risk of developing type 1 diabetes in children with increased genetic susceptibility. The results of the study were published in the Journal of the American Medical Association (JAMA) on January 2, 2018. Read the press release here. We would like to thank everyone who was involved in this study, especially the families who have generously been involved in this study for more than a decade and have been partners in discovery.

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