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Current Research Studies

CHEO-led research programs

The following research studies are open to CHEO patients only. Please consult your physician to find out if you or your child qualify.

Intestinal Microbiome Study:
Patients undergoing a procedure called endoscopy, including those who might have IBD, are being recruited for this study. We are working with our colleagues at the University of Ottawa’s Department of Biochemistry, Microbiology and Immunology to determine whether there are groups of intestinal microbes that may play a role in the inflammation associated with IBD. (Funding source: Canadian Institutes of Health Research)

Ethical and Social Implications of Involving Children with Inflammatory Bowel Disease in Biomedical Research:
Research Ethics Boards (REBs) across Canada and internationally are faced with difficult decisions about children’s involvement in biomedical research. To date, very little research exists to support decisions of REBs in this context. IBD patients have first-hand knowledge of both the burdens and the benefits of research involvement. If research ethics boards are to be able to make informed and ethically justifiable decisions about children’s involvement in biomedical research, systematic studies of the experiences of such populations as IBD patients are essential. Thus, this study will be used to provide guidance for the ethical involvement of children in the context of medical research projects. (Funding source: Genome Canada/CIHR Partnership Grant)
 
MR Enterography Study:
Patients with Crohn’s disease undergoing Magnetic Resonance Imaging of their intestinal tract (MR enterography) are being recruited into this study. We are working with our colleagues in CHEO’s Department of Radiology to determine how accurate MR enterography can be in identifying Crohn’s disease affects on those regions of the intestinal tract we cannot access with our endoscopes. (Funding source: CHEO Research Institute)

Bone Health Study:
Patients newly diagnosed with Crohn’s disease are being recruited into this study. We are working with our colleagues in CHEO’s Division of Endocrinology to determine why some children with Crohn’s disease have bones that are not as strong as they should be; whether there is any improvement over time; and what may be done to improve bone health. (Funding source: Crohn’s and Colitis Foundation of America)

Pediatric-INTERMED Study:
A diagnosis of a chronic condition in a child may be difficult and stressful for the patient and their family. In this CHEO-based study, we are trying to develop a questionnaire tool to identify early on who will likely manage well and who might need additional help. (Funding source: CHAMO Innovation Fund)

Ontario Crohn’s and Colitis Cohort (OCCC):
a. Ontario Crohn’s and Colitis Cohort: Epidemiology and Diagnostic Lag of IBD in Ontario, Canada
b. Inflammatory Bowel Disease in Immigrants to Canada and their Children: Epidemiology and Access to Specialist Care
In this study, health-related information normally gathered by the Government of Ontario is being studied to try to learn more about Crohn’s disease and ulcerative colitis. By looking at a large collection of data, we are looking for answers to such questions as: how common the condition is and whether it’s becoming more common; how best to treat these conditions; and whether there are risk factors for developing the condition. (Funding source: American College of Gastroenterology) Influenza Vaccination in IBD Patients Study: Patients with IBD (Crohn’s disease, ulcerative colitis, indeterminate colitis) are being recruited into this study. We are seeking to have all CHEO IBD patients complete this study. Management of disease activity often requires long-term immunomodulator therapy and so IBD patients treated with these medications are at risk of contracting infections including influenza. We want to determine how many of the children followed in the CHEO IBD Centre receive their flu vaccine and if not whether there are any barriers we should know about. (Funding source: Division of Gastroenterology, Hepatology and Nutrition)

Influencing the Infant Microbiota:
Newborn infants who are being breast fed and their Moms will be recruited into this CHEO based study. As babies develop so do their intestinal tracts. Part of this intestinal tract development is due to the billions of bacteria that start to normally inhabit a baby’s’ bowels. One of the influencers of the type of bacteria that will settle into the intestines may be due to breast milk. The goal of this study is to compare the types of bacteria that are present in the intestinal tract of babies with the type of sugars in breast milk and determine the changes of intestinal bacterial once the breast feeding is stopped. (Funding source: Division of Gastroenterology)
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