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Current Research Studies

CHEO-collaborative Research Programs
 
CIDsCaNN: Canadian Children Inflammatory Bowel Disease Network; a multi-center inception cohort study in new onset IBD:
The Canadian Children IBD network is being established with the major goals of indentifying why IBD develops so commonly in children and adolescents living in Canada, and of determining the best treatment strategies for different types of IBD. Currently recruiting.
(Funding source: CIHR and CHILD Foundation Joint Partnership)
 
Development and Evaluation of the TUMMY CD-index:"
This international study will develop a questionnaire using easy to understand language for kids with Crohn's disease to use. We hope to make it easier for them to tell us how they are feeling and easy enough so patients can fill it out on their own. We hope to better understand from their own words how they are feeling over time. Currently recruiting.
(Funding source: CIHR and CHILD Foundation Joint Partnership) 
 
Development of the PRO-PUCAI or "The TUMMY Index":
The purpose of this study is to determine the best way to transform the PUCAI (pediatric ulcerative colitis activity index tool) into a questionnaire that can be filled out by patients. This new questionnaire will be called the PRO-PUCAI. Because medical language can be difficult to understand, especially for children, it is essential that the wording used in the PRO-PUCAI is clear and age-appropriate.  Currently recruiting.
(Funding source: Shaare Zedek Jerusalem)
 
Impact of Educational Intervention on Influenza Vaccine Attitude in Pediatric IBD:
We want to provide an educational module to inform families and patients with IBD of the benefits and safety of the influenza vaccine, and to determine whether this is a significant motivator for vaccination. We seek to understand the relationship of educational intervention and in-clinic vaccination to vaccine uptake.
Closed to recruitment.
(Funding source: Genome Canada/CIHR Prtnership Grant)
 
ImageKids Project:
The overall objectives of this study is to develop two indices capable of measuring intestinal damage, and, separately, inflammatory disease activity in Pediatric Crohn's disease by means of Magnetic Resonance Imaging with Enterography protocol (MRE). Closed to recruitment.
(Funding source: Shaare Zedek Jerusalem)
 
PROTECT Study:
Children with newly diagnosed Ulcerative colitis will be recruited into this U.S. and Canadian study. The goal of this study is to evaluate the outcome of a best practices protocol for the treatment of ulcerative colitis. Closed to recruitment.
(Funding source: U.S. National Institutes of Health) 

RISK Study:
Patients suspected to have Crohn’s disease are being recruited into this U.S. and Canadian multicenter study. The study will try to find new tests that might predict over the long-term which children will have a more complicated disease course and which will have a very mild course. The study will also try to develop techniques for predicting which therapies will be best for an individual with Crohn’s disease. For more information please visit the Risk Study website. Closed to recruitment.
(Funding source: Crohn’s and Colitis Foundation of America)

Canadian National Early Onset Pediatric IBD Cohort Study (NEOPICS):
Children under the age of 9 who develop ulcerative colitis or Crohn’s disease are being recruited into this Canadian-based study. Genetic influences will be studied in these children to try to determine what triggers development of very early onset IBD. Closed to recruitment. at CHEO
(Funding source: Canadian Institutes of Health Research)

IBD Registry:
Newly diagnosed children with either form of IBD are being recruited into this U.S. and Canadian study. This 10-year-old study is following the disease course and its responses to therapy in some 1,800 children. We hope to better understand what happens over time, what complications may develop, and responses to treatments. Closed to recruitment.
(Funding source: Division of Gastroenterology, Hepatology and Nutrition, CHEO)

Genes and Environment Study:
Children with either form of IBD are being recruited into this study. In collaboration with researchers at Ste. Justine Hospital, we are trying to determine how the environment interacts with an individual’s genetic make-up and how the two in combination affect both disease outcome and responses to therapy. Closed to recruitment. (Funding source: Canadian Institutes of Health Research)

GEM Project:
All healthy brothers and sisters - children and adults - of patients with Crohn’s disease are being recruited into this multicenter Canadian-based study. The goal is to try to determine if there are certain tests that will predict which of the healthy siblings might also develop Crohn’s disease. Closed to recruitment at CHEO. (Funding source: Crohn’s and Colitis Foundation of Canada)
 
OSCI Study:
This U.S. and Canadian-based study was initially started to develop predictors and study outcomes of children who developed severe ulcerative colitis requiring hospitalizations. We are now continuing the long-term follow-up of these patients to determine long-term outcome. Closed to recruitment.
(Funding source: Division of Gastroenterology, Hepatology and Nutrition, CHEO)

Growth Study:
In this, three-centre study - initially funded thought the Crohn’s and Colitis Foundation of America - children were recruited at the time of their Crohn’s disease diagnosis and followed over a two-year period. The three centres are: CHEO, Hospital for Sick Children and the Cincinnati Children's Medical Centre. We are now continuing to follow their progress over a longer period of time. Closed to recruitment.
(Funding source: Division of Gastroenterology, Hepatology and Nutrition, CHEO)
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