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Discovered at CHEO...

 photo of Drs Spotlight on Asthma
Children admitted with asthma leave hospital sooner, thanks to new CHEO study...
In the arena of research, patience is a virtue. It can take years to conduct a study and even more to implement change at the bed side. Then, once in a blue moon, for all the right reasons, an innovative idea leads to a successful study, which has practice-changing results, and becomes a hospital clinical pathway immediately - even before the study is published.

That is exactly what happened when CHEO resident Dr. Victoria Gelt came to Dr. Catherine Pound, pediatrician at CHEO and assistant professor at University of Ottawa. Dr. Gelt noticed that the procedure in which children with severe asthma were being weaned from their Ventolin was resulting in longer hospital stays. She suggested that the nurses, who were already responsible for noting when a child should be weaned, should be given more control in the process.
  Spotlight on Arthritis
Teens Take Charge: A new evidence-based online resource for teens with juvenile idiopathic arthritis (JIA)

It is a common assumption that arthritis is a disease that affects adults only, however an estimated 24,000 Canadian children and teens live with one or more forms of childhood arthritis, of which juvenile idiopathic arthritis (JIA) is the most common, affecting about 10,000 (one in 1,000) children in Canada. JIA causes inflammation in the joints and impacts kids’ and teens’ physical, emotional and social wellbeing.

In an effort to help teens with JIA better manage their arthritis and improve their transition to adult health care, a team of researchers from 11 academic centres across Canada, including the Children’s Hospital of Eastern Ontario (CHEO) , developed and tested an online program called ‘Teens Taking Charge: Managing JIA Online Program’.

  Spotlight on Cancer
Halt, who goes there?
Every day our immune system asks that question billions of times, killing off tiny intruders (microbes) and unwanted guests (cancer cells). But cancer cells often have the secret password needed to get past the immune checkpoint guards.

Researchers at the Children’s Hospital of Eastern Ontario (CHEO) in Ottawa for decades have been acting like spymasters, collecting, analyzing and creating scientific intelligence on the mechanics at play in this high-stakes espionage and counter-espionage among cells.

A team led by Dr. Robert Korneluk, distinguished professor at the University of Ottawa and a senior scientist at the CHEO Research Institute, recently found that a combination of immunotherapies act like double-agents, delivering a one-two punch to brain cancer tumours in laboratory testing.
  Spotlight on Rare Disease
A National Rare Disease Team Led from CHEO

The use of next-generation sequencing to pinpoint the genetic mutations behind rare diseases is one of the great success stories of Care4Rare. In its 4th year, the nation-wide network of doctors, scientists and clinical researchers is dedicated to improving the diagnosis and treatment of rare diseases. The challenge is great; 7000 rare diseases with more than half not yet understood and only 200 therapies available. However, with novel DNA technology, researchers at CHEO can look through an individual’s entire genetic code of 22,000 genes and spot things that don’t belong. The hunt itself is like finding a single typo in four copies of Leo Tolstoy’s epic novel War and Peace.

As such, Care4Rare is making tremendous progress in equipping families with answers when their children present with mysterious symptoms. Read more...

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