CHEO Research Institute Logo
Decrease Text SizeIncrease Text SizeFacebookTwitterYoutube

coordinators at a seminar  
What's New rss


CHEO Research Institute 2017-18 CHAMO Innovation Fund competition

The CHEO Research Institute is happy to announce the results of the 2017-18 CHAMO Innovation Fund competition. Funds from the competition are to support the development of new and innovative approaches to health care delivery and to provide leadership in the dissemination of new knowledge across the healthcare system. These projects will no doubt impact healthcare delivery and offer opportunities to translate new knowledge into medical practice locally and nationally.

Congratulations go out to the following successful applicants and their teams:

Dr Matthew Lines ($65,627.85) for the project entitled “Whole-metabolomic studies of treatment effect in patients with genetically-defined inborn errors of metabolism.” Metabolism is the complex set of interlinked chemical reactions which sustain all living things. Inborn errors of metabolism (IEMs) are a group of rare genetic disorders affecting one or more of the body’s metabolic pathways. Untreated, the cells of patients with an IEM tend to over- or underproduce specific chemical compounds (metabolites) which are the particular to that type of IEM, leading to disease. The genes responsible for IEMs cannot currently be repaired; rather, the usual aim of treatment is to offload the affected pathway(s) using a special diet or medications. Treatment of IEM patients is heavily reliant on the laboratory. Historically, this has required a battery of several laboratory tests, each of which tests a small group of related metabolites; testing is complex and resource-intensive. Although we know that metabolic pathways are highly interconnected, the broader metabolic consequences of IEMs and their treatments on are poorly understood. In this study, we will use a powerful new technology, targeted metabolomics, to assess overall metabolism in patients with IEMs, in order to (i) identify pathways secondarily impacted in various IEMs, and (ii) assess the metabolic effects of IEM treatment.

Dr. Kathleen Pajer and Dr. William Gardner ($91,646.85) for the project entitled “Patient-Generated Goals in Mental Health Care: Better Outcomes?” Researchers believe that clinical care can be improved by engaging patients and families directly in planning the care process. Engagement efforts have included asking patients/families to provide information about whether they are getting better. But what does “getting better” mean? The merits of surveys, questionnaires, or rating scales have been widely discussed. Should they be disorder-specific or global? What should we do if patients have difficulty reading or understanding these instruments? Investigators in the UK have proposed a simple solution: ask the patients and families what their primary goal treatment goal is and track progress together on that goal (Goal-Based Outcomes or GBO). Although there has been some work to suggest that this is helpful, it has never been tested in a controlled way. Our study will do a special type of randomized controlled trial to test whether GBO improves clinical care in child and youth mental health. Although we will use this in child and youth mental health care, if it is successful, it can be tested and applied in any care setting with any type of medical problem. This could change practice at CHEO and throughout Canada.

Dr. Dhenuka Radhakrishnan ($89,486.85) for the project entitled “Derivation of a clinical score to predict risk of future emergency department visits and hospitalizations among children with asthma.” Background: Asthma is a common chronic childhood disease and a leading cause of emergency department (ED) visits and hospitalizations. Currently, most children who leave the ED after an asthma visit do not receive proven preventative treatments such as asthma education. However, these treatments are only needed for children at high-risk for repeat visits. There are no guidelines to direct clinicians how to practically identify these high-risk children before discharge from the ED. Aims: Derive a clinical risk score to identify children at high-risk for repeat asthma visits within a year after a first asthma ED visit. Methods: We will analyze data collected in a previous study that included 1012 children who visited the ED for asthma at one of five pediatric hospitals. We will link information on participants of this previous study with Ontario and Quebec health administrative data to identify repeat ED or hospital visits over the following year. This will enable development of a clinical score to identify high-risk asthma patients. Importance: This study will provide a method to identify children at high risk for future asthma ED visits or hospitalizations and in future, to target treatments to children who would benefit most.

Dr. Melise Keays ($91,467.12) for the project entitled “Leveraging the electronic medical record (Epic) to create a highly functional research data network for observational studies in Canada.” CHEO and SickKids are implementing a single, integrated instance of their electronic medical record system (EMR). The EMR allows health care providers to have all vital patient information at their fingertips to provide patients with optimal care. It also presents a unique opportunity to leverage regularly collected health data to help answer important questions that previously were not possible to answer without expensive randomized clinical trials. In this collaborative effort, we propose to establish the local IT and research infrastructure to develop and lead diverse multi-centre programs of research, and improve care, with meaningful patient involvement. We will seek multi-stakeholder feedback and propose a robust platform for clinical monitoring, quality improvement, and leading research in unique patient populations. The anticipated outcome of this project is to provide a blueprint for creating new, highly functional research data networks to conduct rigorous observational studies in Canada.

Dr. Dayre McNally ($91,399.35) for the project entitled “Transforming Health Information and Research Synthesis through Technology (THIRST).” Clinicians and hospital policy makers rely on systematic reviews to help provide optimal cost-effective health care. Systematics reviews are comprehensive knowledge synthesis efforts that are very time consuming as the study team often needs to review thousands of research articles to answer a specific question. Unfortunately, with the rapid increase in rate of published literature, it is becoming increasingly difficult to complete these reviews. The good news is that it may be possible to avoid the impending crisis by taking advantage of technological advances that allow for a large online scientific community and computer automation to provide assistance. In collaboration with Algonquin College and the National Research Council, we have initiated development of a web-based platform (insightScope) that incorporates these two solutions into one easy-to-use free website. The proposed study aims to complete development and perform two types of user testing. We will recruit at least 25 study teams to use the prototype insightScope platform and provide feedback on workflow and usability. Study teams will be recruited from the 5 major Ontario pediatric hospital and established Canadian pediatric research consortium.
Take Action
Quick Links

Our Researchmagnifying glass

abcefg hijklmnopqrst uvwxyz