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Nathalie Lepage
Clinical Investigator, CHEO Research Institute
Head, Biochemical Genetics laboratory, CHEO
Full Professor, Department of Pathology and Laboratory Medicine,
Faculty of Medicine, University of Ottawa
613-737-7600 Ext. 2439
Current Research:
Dr. Lepage is currently involved with a National multicenter research project that aims to establish pediatric reference intervals for biochemical markers of pediatric diseases. She is also active with the Ontario prenatal screening for Down syndrome and open neural tube defects to ensure best practices are offered in the province. A third aspect of Dr. Lepage’s research interest is the development of laboratory methods for markers of Biochemical Genetics and biochemistry laboratories.
Research Team:
  • Chantal Horth
  • Barbara Murchison
Dr. Lepage is the Head of the Biochemical Genetics laboratory. She is the laboratory director for the Hawkesbury General Hospital and a laboratory consultant for clinical Biochemistry at Montfort Hospital. She is a fellow from the Canadian Academy of Clinical Biochemistry and a fellow from the Canadian College of Medical Geneticists.

Dr. Lepage is involved in many National and International committees: Pediatric, Maternal-Fetal division of the American Association of Clinical Chemistry, Canadian Academy of Clinical Biochemistry board of directors, Ontario external quality assurance program. She is a member of the joint 2013 AACC/CSCC annual meeting organizing committee.
Sample Publications:
Filler G and Nathalie Lepage. Cystatin C Adaptation in the First Month of Life. Pediatric Nephrology 28:991-994, 2013.

Plaut D, Nathalie Lepage. Biological Variation: Validity, sources are explored. Advance for Medical Laboratory Professionals, July 2013.

Huang T, Meschino WS, Okun N, Dennis A, Hoffman B, Nathalie Lepage, Rashid S, Aul R, Farrell SA. The Impact of Maternal Weight Discrepancies on Prenatal Screening Results for Down Syndrome. Prenatal Diagnosis 33:471-476, 2013.

Nathalie Lepage, Chaudhry A, Konforte D, Shaw J, Veljkovic K, Dennis A, Rashid S, Farrell SA. Standardized Procedural Practices of the Ontario Prenatal Screening Program for aneuploidies and open neural tube defects. Clinical Biochemistry 45:1152-1157, 2012.
Bariciak E, Yasin A, Harrold J, Walker M, Nathalie Lepage, Filler G. Preliminary reference intervals for cystatin C and beta-trace protein in preterm and neonates. Clinical Biochemistry 44:1156-1159, 2011.

White CA, Rule AD, Collier CP, Akbari A, Lieske JC, Nathalie Lepage, Doucette S, Knoll GA. The impact of interlaboratory differences in cystatin C assay measurement on glomerular filtration rate estimation. Clinical Journal of American Society of Nephrology 6:2150-2156, 2011.

Tsamparielos A, Nathalie Lepage, Feber J. Intra-Individual Variability of the modified Schwartz and novel CKiD GFR Equations in Pediatric Renal Transplant Patients. Pediatric Transplantation 15: 760-765, 2011.

Al-Dirbashi OY, Kölker S, Ng D, Fisher L, Rupar T, Nathalie Lepage, Rashed MS, Santa T, Goodman SI, Geraghty M, Zschocke J, Christensen E, Hoffmann GF, Chakraborty P. Diagnosis of glutaric aciduria type 1 by measuring 3-hydroxyglutaric acid in dried urine spots by liquid chromatography tandem mass spectrometry. Journal of Inherited Metabolic Disease 34:1, 173-180, 2011.
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