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Bernard Th├ębaud photo of Bernard Thebaud
Senior Scientist, Regenerative Medicine, CHEO Research Institute &
Ottawa Hospital Research Institute
Pediatrician, Division of Neonatology, CHEO
Professor of Pediatrics, University of Ottawa

bthebaud@ohri.ca
Research Practice Areas:
Current Research:

Our lab is focused on understanding the mechanisms of lung development, injury, and repair in order to design new treatments for incurable lung diseases. We have an ambitious research program set out to study clinically relevant questions in the lab for translation into real-life applications. All animal models of human lung disease are available in our lab, and we correlate structural and functional changes to assess the clinical relevance of the experimental therapies we are testing.

Our major research contributions over the past seven years include (i) the discovery of the role of angiogenesis in normal lung development and repair, and (ii) the demonstration of the therapeutic potential of stem cells in experimental bronchopulmonary dysplasia, asthma, chronic obstructive pulmonary disease, and pulmonary hypertension.

Over the next five years, our goal is to bring safe and effective cell-based therapies for lung diseases into the clinic, and thereby create vast improvements in patient outcomes.

Achievements:
2011 Canada Research Chair in Lung Development, Injury and Repair
2009 Clinical Scholar, Alberta Heritage Foundation for Medical Research
2008 CIHR, Institute for Human Development, Child and Youth Health, “Rising Star in Perinatal Research” New Investigator Award
2007 Sanofi Pasteur Research Award, “Best in Current Canadian Child Health Research”
Sample Publications:
Lesage F, Thébaud B. Nanotherapies for micropreemies: Stem cells and the secretome in bronchopulmonary dysplasia. Semin Perinatol. 2018 Oct 6. pii: S0146-005(18)30085-5. doi: 10.1053/j.semperi.2018.09.007. [Epub ahead of print] Review.

Guillot M, Offringa M, Lacaze-Masmonteil T, Thébaud B. Cell-Based Therapy for Bronchopulmonary Dysplasia in Preterm Infants: Workshop report. Can J Physiol Pharmacol. 2018 Oct 5. doi: 10.1139/cjpp-2018-0342. [Epub ahead of print]

Thébaud B. Stem cell-based therapies in neonatology: a new hope. Arch Dis Child Fetal Neonatal Ed. 2018 Nov;103(6):F583-F588. doi: 10.1136/archdischild-2017-314451. Epub 2018 Jul 4. Review.
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