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Bernard Th├ębaud photo of Bernard Thebaud
Senior Scientist, Regenerative Medicine, CHEO Research Institute &
Ottawa Hospital Research Institute
Pediatrician, Division of Neonatology, CHEO
Professor of Pediatrics, University of Ottawa
Research Practice Areas:
Current Research:

Our lab is focused on understanding the mechanisms of lung development, injury, and repair in order to design new treatments for incurable lung diseases. We have an ambitious research program set out to study clinically relevant questions in the lab for translation into real-life applications. All animal models of human lung disease are available in our lab, and we correlate structural and functional changes to assess the clinical relevance of the experimental therapies we are testing.

Our major research contributions over the past seven years include (i) the discovery of the role of angiogenesis in normal lung development and repair, and (ii) the demonstration of the therapeutic potential of stem cells in experimental bronchopulmonary dysplasia, asthma, chronic obstructive pulmonary disease, and pulmonary hypertension.

Over the next five years, our goal is to bring safe and effective cell-based therapies for lung diseases into the clinic, and thereby create vast improvements in patient outcomes.

2011 Canada Research Chair in Lung Development, Injury and Repair
2009 Clinical Scholar, Alberta Heritage Foundation for Medical Research
2008 CIHR, Institute for Human Development, Child and Youth Health, “Rising Star in Perinatal Research” New Investigator Award
2007 Sanofi Pasteur Research Award, “Best in Current Canadian Child Health Research”
Sample Publications:
Waszak P, Alphonse R, Vadivel A, Ionescu L, Eaton F, Thébaud B. Preconditioning enhances the paracrine effect of mesenchymal stem cells in preventing oxygen-induced neonatal lung injury in rats. Stem Cells Dev. 2012 Oct 10;21(15):2789-97. doi: 10.1089/scd.2010.0566. Epub 2012 Jun 7.

Ionescu L, Byrne RN, van Haaften T, Vadivel A, Alphonse RS, Rey-Parra GJ, Weissmann G, Hall A, Eaton F, Thébaud B. Stem cell conditioned medium improves acute lung injury in mice: in vivo evidence for stem cell paracrine action. Am J Physiol Lung Cell Mol Physiol. 2012 Sep 28. [Epub ahead of print]

Vadivel A, van Haaften T, Alphonse RS, Rey-Parra GJ, Ionescu L, Haromy A, Eaton F, Michelakis E, Thébaud B. Critical role of the axonal guidance cue EphrinB2 in lung growth, angiogenesis, and repair. Am J Respir Crit Care Med. 2012 Mar 1;185(5):564-74. Epub 2011 Dec 8.

Ionescu LI, Alphonse RS, Arizmendi N, Morgan B, Abel M, Eaton F, Duszyk M, Viagoftis H, Aprahamian TR, Walsh K, Thébaud B. Airway delivery of soluble factors from plastic-adherent bone marrow cells prevents murine asthma. Am J Respir Cell Mol Biol. 2012 Feb;46(2):207-16. Epub 2011 Sep 8.

Note: A complete list of publications may be found in PubMed (search by last name and first initial).
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