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Tommy Alain
Scientist, CHEO Research Institute
Assistant Professor, Department of Biochemistry,
Microbiology and Immunology, University of Ottawa
613-737-7600 Ext. 4198
Research Practice Areas:
Current Research:

Tommy Alain, Ph.D., is a newly appointed Scientist at the Children’s Hospital of Eastern Ontario Research Institute, and an Assistant Professor of Biochemistry, Microbiology and Immunology at the University of Ottawa. His training is in virology, innate immune responses, cell biology, and oncology. During his doctoral research, he studied the virology and the oncolytic potencies of reovirus, vesicular stomatitis virus, and myxoma virus against brain cancers under the mentorship of two pioneers of oncolytic viruses in Canada, Dr. Peter Forsyth and Dr. Patrick Lee at the University of Calgary. He then pursued his post-doctoral studies at McGill University in the laboratory of Dr. Nahum Sonenberg, a world-leading expert in mRNA translational control, where he expanded his technical expertise in the control of translation initiation and the mammalian target of rapamycin (mTOR) signaling pathway, linking both viral immunity and oncology research. His work on how the translation initiation factor eIF4E and downstream effectors of mTOR modulate innate immune responses to viruses, as well as anti-proliferative efficacies of anti-cancer therapeutics, led to a number of high profile publications. To date, Dr. Alain has published over 40 reports. He maintains numerous national and international collaborations with scientists in the academic and private sectors. Dr. Alain is also a member of the Canadian Oncolytic Virus Consortium led by Dr. John Bell at the Ottawa Hospital Research Institute. 

Research Team:
  • Bruno Fonseca - Research Associate
  • Tyson Graber - Research Associate
  • Danielle Healy - Masters Student
  • Dung Hoang - PhD Student
  • Jian-Jun Jia - Research Assistant
  • Jean Leopold Kabambi - Honours Student
  • Izzy Linares - Summer Student
  • Fern McSorley - Visiting PostDoc
To learn more, please visit the Tommy Alain laboratory website.

Sample Publications:
Alain T, Morita M, Fonseca BD, Yanagiya A, Siddiqui N, Bhat M, Zammit D, Markus V, Metrakos P, Voyer LA, Gandin V, Liu Y, Topisirovic I, Sonenberg N. eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies. Cancer Res. 2012 Dec 15;72(24):6468-6476.

Alain T, Lun XQ, Martineau Y, Sean P, Pulendran B, Petroulakis E, Zemp F, Lemay C, Roy D, Forsyth PA, Costa-Mattioli M, Sonenberg N. Vesicular stomatitis virus oncolysis is potentiated by mTORC1-dependent inhibition of type-I IFN production. PNAS. 2010 Jan 26;107(4):1576-81.

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