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Christine Armour photo of Christine Armour
Physician (Clinical Geneticist), Department of Genetics
Children’s Hospital of Eastern Ontario (CHEO)
Assistant Professor, Department of Pediatrics, University of Ottawa
Clinical Investigator, CHEO Research Institute
Research Practice Areas:
Current Research:
Dr. Armour’s main research activity relates to non-invasive detection of fetal genetic conditions from maternal blood. Using different next generation sequencing techniques we are developing the technology and expertise to screen for fetal aneuploidies, small chromosomal deletions and single gene changes present in the fetus without posing any risk to the pregnancy. We are studying different methodologies as well as the feasibility of clinical translation with the goal of applying the techniques to numerous aspects of prenatal and newborn care. Dr. Armour also collaborates with other researchers in the identification and characterization of rare genetic conditions.
Research Team:
  • Dr. Yanwei Xi - Post-doctoral fellow
Dr. Armour is a Clinical Geneticist at the Children’s Hospital of Eastern Ontario, a Clinical Investigator at the CHEO Research Institute and an Assistant Professor in the Department of Pediatrics at the University of Ottawa. She completed the Royal College of Physician and Surgeons training program in Medical Genetics at the University of Ottawa in 2008, after completing medical school at Queen’s University in 2001. She
also received an MSc in Biochemistry in 1997 from the University of Ottawa. Dr. Armour’s main interest is non-invasive prenatal testing using next generation sequencing from cell free DNA, both current and future uses. She is also engaged in the characterization of rare genetic conditions and genotype-phenotype correlations.
Sample Publications:
Armour CM, Nikkel SN. “Five things to know about….Noninvasive prenatal testing from cell-free DNA” CMAJ 2014 online April 7, 2014.

Armour CM., Brebner A, Watkins D., Geraghty M.T. Chan A., Rosenblatt DS. A Patient With an Inborn Error of Vitamin B12 Metabolism (cblF) Detected by Newborn Screening 2013 Pediatrics Jul;132(1):e257-61

Peltekova I, Macdonald A, Armour CM. Microduplication on 3p25 in a patient with 3p Deletion Syndrome. 2012. Am J Med Genet. Oct;158A(10):2583-6.

Rivière JB, Mirzaa GM, O'Roak BJ, Beddaoui M, Alcantara D, Conway RL, St-Onge J, Schwartzentruber JA, Gripp KW, Nikkel SM, Worthylake T, Sullivan CT, Ward TR, Butler HE, Kramer NA, Albrecht B, Armour CM, Armstrong L, Caluseriu O, Cytrynbaum C, Drolet BA, Innes AM, Lauzon JL, Lin AE, Mancini GM, Meschino WS, Reggin JD, Saggar AK, Lerman-Sagie T, Uyanik G, Weksberg R, Zirn
B, Beaulieu CL; Finding of Rare Disease Genes (FORGE) Canada Consortium, Majewski J, Bulman DE, O'Driscoll M, Shendure J, Graham JM Jr, Boycott KM, Dobyns WB. De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes. Nat Genet. 2012 Epub Jun 24

Hull D, Davies G, Armour CM. Survey of prenatal counselling practices regarding aneuploidy risk modification, invasive diagnostic procedure risks, and procedure eligibility criteria across Canadian centers. J Obstet Gynaecol Can 2012;34(7):626–636
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