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Matthew Lines photo of Dr. Matthew Lines
Investigator, CHEO Research Institute
Physician, Division of Metabolics, CHEO
Assistant Professor, Department of Medicine,
Faculty of Medicine, University of Ottawa
613-737-7600 Ext. 1351
Current Research:
Dr. Lines is interested in how mitochondrial dysfunction results in disease and improving how mitochondrial disorders are diagnosed. In addition, through his work, Dr. Lines is hoping to improve treatment of rare mitochondrial disease.
Dr. Matthew Lines is a Clinical Investigator at the CHEO Research Institute and a Physician in the Department of Metabolics at CHEO. He is also an Assistant Professor at the University of Ottawa. His current research interests include the diagnosis and characterization of mitochondrial disorders and the application of massively parallel sequencing technologies to the specific diagnosis of rare genetic diseases.
Sample Publications:
Glinton KE, Benke PJ, Lines MA, Geraghty MT, Chakraborty P, Al-Dirbashi OY, Jiang Y, Kennedy AD, Grotewiel MS, Sutton VR, Elsea SH, El-Hattab AW. Disturbed phospholipid metabolism in serine biosynthesis defects revealed by metabolomic profiling. Mol Genet Metab. 2018 Mar;123(3):309-316. doi: 10.1016/j.ymgme.2017.12.009. Epub 2017 Dec 12.

Lines MA, Ito Y, Kernohan KD, Mears W, Hurteau-Miller J, Venkateswaran S, Ward L, Khatchadourian K, McClintock J, Bhola P; Care4Rare Consortium, Campeau PM, Boycott KM, Michaud J, van Kuilenburg AB, Ferdinandusse S, Dyment DA. Yunis-Varón syndrome caused by biallelic VAC14 mutations. Eur J Hum Genet. 2017 Sep;25(9):1049-1054. doi: 10.1038/ejhg.2017.99. Epub 2017 Jun 21

Antoun G, McBride S, Vanstone JR, Naas T, Michaud J, Redpath S, McMillan HJ, Brophy J, Daoud H, Chakraborty P, Dyment D, Holcik M, Harper ME, Lines MA. Detailed Biochemical and Bioenergetic Characterization of FBXL4-Related Encephalomyopathic Mitochondrial DNA Depletion. JIMD Rep. 2016;27:1-9. doi: 10.1007/8904_2015_491. Epub 2015 Sep 25.
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