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Dayre McNally
Pediatric Intensivist, Department of Pediatrics, CHEO
Scientist, CHEO Research Institute

dmcnally@cheo.on.ca
613-737-7600 Ext. 3553
Research Practice Areas:
Current Research:
Dr. McNally’s research investigates the role of vitamins, including vitamin D, in pediatric critical illness. This research has recently demonstrated that lower levels of vitamin D worsen critical illness and prolong PICU admission, and that blood levels of vitamin D levels are inadequate following surgery. Ongoing research studies are designed to determine how to optimize the vitamin D status of critically ill children through both pre-illness supplementation and post-illness rapid restoration strategies.

Research Team:
Biography:

Dr. McNally is a Clinical Investigator at the CHEO Research Institute, and a Pediatric Intensivist with the Department of Pediatrics at CHEO. Dr. McNally has a PhD in biochemistry and is currently completing an MSc in clinical epidemiology.

Achievements:

r. McNally was awarded a Grant-in-Aid Award from the Heart and Stroke Foundation of Canada for his work entitled, "Prevention of vitamin D deficiency after congenital heart disease surgery: a dose evaluation trial". Recent work done at CHEO by the PICU research group demonstrated that four out of every five congenital heart disease patients have inadequate blood levels of vitamin D following surgery. There is evidence that optimization of vitamin D status following congenital heart disease repair could lessen inflammation, reduce nosocomial infection and improve cardiac function. This proposal aims to determine whether pre-operative administration of a higher daily dose of vitamin D can safely prevent vitamin D deficiency following surgery.

Sample Publications:
Menon K, McNally JD, Choong K, Ward R, Lawson M, Ramsay T, Wong HR. A survey of stated physician practices and beliefs on the use of steroids in pediatric fluid and/or vasoactive infusion-dependent shock [published online ahead of print April 26, 2013]. Pediatr Crit Care Med. doi: 10.1097/PCC.0b013e31828a7287

McNally JD, Doherty DR, Lawson ML, Al-Dirbashi OY, Chakraborty P, Ramsay T, Menon K. The relationship between vitamin d status and adrenal insufficiency in critically ill children [published online ahead of print April 1, 2013]. J Clin Endocrinol Metab. doi: 10.1210/jc.2013-1126

McNally JD, Menon K, Chakraborty P, Fisher L, Williams KA, Al-Dirbashi OY, Girolamo T, Mahjarah GM, Doherty DR. Impact of anesthesia and surgery for congenital heart disease on the vitamin D status if infants and children: A prospective longitudinal study [published online ahead of print March 6, 2013]. Anesthesiology. doi: 10.1097/ALN.0b013e31828ce817

McNally JD, Menon K, Chakraborty P, Fisher L, Williams KA, Al-Dirbashi OY, Doherty DR; Canadian Critical Care Trials Group. The association of vitamin D status with pediatric critical illness. Pediatrics. 2012 130(3): 429-36.

Leis K, McNally JD, Montgomery, MR, Sankaran K, Karuananyake C, Rosenberg AM. Vitamin D intake in Young Children with Acute Lower Respiratory Tract Infection. CJCP. 2012 14(1): 1-6.
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