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David Mack, MD photo of David Mack
Senior Scientist, CHEO Research Institute
Director, CHEO Inflammatory Bowel Disease Centre
Chief, Division of Gastroenterology, Hepatology & Nutrition, CHEO
Professor, Department of Pediatrics, Faculty of Medicine, University of Ottawa

613-737-7600 Ext. 3817
Research Practice Areas:
Current Research:
The philosophy of Dr. Mack’s team is to rapidly translate research findings into effective care using a multi-faceted, integrative approach. Studies can start through the CHEO IBD Centre, such as those done recently on diagnostics in pediatric IBD. Current interdivisional collaborations include examining bone health, biopsychosocial functioning and intestinal imaging. A recent interdepartmental effort with University of Ottawa researchers will provide understanding of the intestinal microbiome in gut inflammation. Multi-center initiatives at the national and international levels are underway to understand why IBD is increasing in children; mechanisms of inflammation; predicting outcome; developing best practices; and understanding of the natural history of pediatric IBD.
Research Team:
Biography:

Dr. Mack completed his pediatric gastroenterology fellowship at the Hospital for Sick Children, University of Toronto. After a decade at the University of Nebraska Medical Centre he returned to Canada to expand the field of Pediatric Gastroenterology at CHEO. Currently, Dr Mack is the Chief of the Division and Director of the CHEO IBD Centre. There are a number of areas the Centre actively pursues including ensuring excellence in clinical care, providing education and expanding research in various domains. Dr. Mack has served as the Canadian Councillor for the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.

Sample Publications:
Chuong KH, Mack DR, Stintzi A, O'Doherty KC.

OMICS. 2017 Mar 10. doi: 10.1089/omi.2016.0185. [Epub ahead of print] PMID:28282257

Kugathasan S, Denson LA, Walters TD, Kim MO, Marigorta UM, Schirmer M, Mondal K, Liu C, Griffiths A, Noe JD, Crandall WV, Snapper S, Rabizadeh S, Rosh JR, Shapiro JM, Guthery S, Mack DR, Kellermayer R, Kappelman MD, Steiner S, Moulton DE, Keljo D, Cohen S, Oliva-Hemker M, Heyman MB, Otley AR, Baker SS, Evans JS, Kirschner BS, Patel AS, Ziring D, Trapnell BC, Sylvester FA, Stephens MC, Baldassano RN, Markowitz JF, Cho J, Xavier RJ, Huttenhower C, Aronow BJ, Gibson G, Hyams JS, Dubinsky MC.
Lancet. 2017 Mar 1. pii: S0140-6736(17)30317-3. doi: 10.1016/S0140-6736(17)30317-3. [Epub ahead of print] PMID:28259484
 
Rosen MJ, Karns R, Vallance JE, Bezold R, Waddell A, Collins MH, Haberman Y, Minar P, Baldassano RN, Hyams JS, Baker SS, Kellermayer R, Noe JD, Griffiths AM, Rosh JR, Crandall WV, Heyman MB, Mack DR, Kappelman MD, Markowitz J, Moulton DE, Leleiko NS, Walters TD, Kugathasan S, Wilson KT, Hogan SP, Denson LA.
Gastroenterology. 2017 Jan 26. pii: S0016-5085(17)30073-2. doi: 10.1053/j.gastro.2017.01.016. [Epub ahead of print]PMID:28132889
 
Mottawea W, Chiang CK, Mühlbauer M, Starr AE, Butcher J, Abujamel T, Deeke SA, Brandel A, Zhou H, Shokralla S, Hajibabaei M, Singleton R, Benchimol EI, Jobin C, Mack DR, Figeys D, Stintzi A.

Nat Commun. 2016 Nov 23;7:13419. doi: 10.1038/ncomms13419. PMID:27876802

Benchimol EI, Manuel DG, Mojaverian N, Mack DR, Nguyen GC, To T, Guttmann A.
Inflamm Bowel Dis. 2016 Oct;22(10):2482-90. doi: 10.1097/MIB.0000000000000905. PMID 27556836
 
Zhang X, Ning Z, Mayne J, Deeke SA, Li J, Starr AE, Chen R, Singleton R, Butcher J, Mack DR, Stintzi A, Figeys D.
Anal Chem. 2016 Jun 21;88(12):6120-5. doi: 10.1021/acs.analchem.6b01412. PMID:27248155
 
Starr AE, Deeke SA, Ning Z, Chiang CK, Zhang X, Mottawea W, Singleton R, Benchimol EI, Wen M, Mack DR, Stintzi A, Figeys D.

Gut. 2016 May 23. pii: gutjnl-2015-310705. doi: 10.1136/gutjnl-2015-310705. [Epub ahead of print] PMID:27216938

Huth K, Benchimol EI, Aglipay M, Mack DR.
Strategies to Improve Influenza Vaccination in Pediatric Inflammatory Bowel Disease Through Education and Access. Inflamm Bowel Dis. 2015 Aug;21(8):1761-8. doi: 10.1097/MIB.0000000000000425. PMID:26199989
 
Benchimol EI, Manuel DG, To T, Mack DR, Nguyen GC, Gommerman JL, Croitoru K, Mojaverian N, Wang X, Quach P, Guttmann A.

PLoS One. 2015 Apr 7;10(4):e0123599. doi: 10.1371/journal.pone.0123599. PMID:25849480

 
Turner D, Koletzko S, Griffiths AM, Hyams J, Dubinsky M, de Ridder L, Escher J, Lionetti P, Cucchiara S, Lentze MJ, Koletzko B, van Rheenen P, Russell RK, Mack D, Veereman G, Vermeire S, Ruemmele F. Use of Placebo in Pediatric Inflammatory Bowel Diseases: A Position Paper from ESPGHAN, ECCO, PIBDnet and the Canadian Children IBD Network. J Pediatr Gastroenterol Nutr. 2015 Nov 3 PMID:26545204
 
Benchimol EI, Mack DR, Nguyen GC. Response to Fuller-Thomson. Am J Gastroenterol. 2015 Sep;110(9):1371-2 PMID:26348310
 
Huth K, Benchimol EI, Aglipay M, Mack DRStrategies to Improve Influenza Vaccination in Pediatric Inflammatory Bowel Disease Through Education and Access. Inflamm Bowel Dis. 2015 Aug;21(8):1761-8 PMID:26199989
 
Livshits A, Fisher D, Hadas I, Bdolah-Abram T, Mack D, Hyams J, Crandall W, Griffiths AM, Turner D. Abdominal X-Ray in Pediatric Acute Severe Colitis and Radiographic Predictors of Response to Intravenous Steroids. J Pediatr Gastroenterol Nutr. 2015 Jul 20 PMID:26196204
 
Cutler DJ, Zwick ME, Okou DT, Prahalad S, Walters T, Guthery SL, Dubinsky M, Baldassano R, Crandall WV, Rosh J, Markowitz J, Stephens M, Kellermayer R, Pfefferkorn M, Heyman MB, LeLeiko N, Mack D, Moulton D, Kappelman MD, Kumar A, Prince J, Bose P, Mondal K, Ramachandran D, Bohnsack JF, Griffiths AM, Haberman Y, Essers J, Thompson SD, Aronow B, Keljo DJ, Hyams JS, Denson LA; PRO-KIIDS Research Group, Kugathasan S. Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping.
PLoS One. 2015 Jun 22;10(6) PMID:26098103
 
Oliva-Hemker M, Hutfless S, Al Kazzi ES, Lerer T, Mack D, LeLeiko N, Griffiths A, Cabrera J, Otley A, Rick J, Bousvaros A, Rosh J,Grossman A, Saeed S, Kay M, Carvalho R, Keljo D, Pfefferkorn M, Faubion W Jr, Kappelman M, Sudel B, Schaefer ME, Markowitz J, Hyams JS. Clinical Presentation and Five-Year Therapeutic Management of Very Early-Onset Inflammatory Bowel Disease in a Large North American Cohort  J Pediatr. 2015 Sep;167(3):527-32.e1-3. PMID:25982142
 
Mahmud FH, De Melo EN, Noordin K, Assor E, Sahota K, Davies-Shaw J, Cutz E, Somers G, Lawson M, Mack DR, Gallego P, McDonald C, Beaton MD, Bax K, Saibil F, Gilbert J, Kirsch S, Perkins BA, Cino M, Szentgyorgyi E, Koltin D, Parikh A, Mukerji G, Advani A, Lou O, Marcon MA. The Celiac Disease and Diabetes-Dietary Intervention and Evaluation Trial (CD-DIET) protocol: a randomised controlled study to evaluate treatment of asymptomatic coeliac disease in type 1 diabetes. BMJ Open. 2015 May 11;5(5):e008097 PMID:25968008
 
Grossi V, Lerer T, Griffiths A, LeLeiko N, Cabrera J, Otley A, Rick J, Mack D, Bousvaros A, Rosh J, Grossman A, Saeed S, Kay M, Boyle B, Oliva-Hemker M, Keljo D, Pfefferkorn M, Faubion W, Kappelman MD, Sudel B, Markowitz J, Hyams JS. Concomitant Use of Immunomodulators Affects the Durability of Infliximab Therapy in Children With Crohn's Disease. Clin Gastroenterol Hepatol. 2015 Oct;13(10):1748-56 PMID:25911120
 
Benchimol EI, Manuel DG, To T, Mack DR, Nguyen GC, Gommerman JL, Croitoru K, Mojaverian N, Wang X, Quach P, Guttmann A.
 
Benchimol EI, Mack DR, Guttmann A, Nguyen GC, To T, Mojaverian N, Quach P, Manuel DG. Inflammatory bowel disease in immigrants to Canada and their children: a population-based cohort study. Am J Gastroenterol. 2015 Apr;110(4):553-63 PMID:25756238
 
Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters TD, Aronow B, Xavier RJ, Gevers D, Denson LA. Corrigendum. Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest. 2015 Mar 2;125(3):1363 PMID:25729854
 
Unger S, Stintzi A, Shah P, Mack D, O'Connor DL.Gut microbiota of the very-low-birth-weight infant. Pediatr Res. 2015 Jan;77(1-2):205-13. doi: 10.1038/pr.2014 PMID:25310760
 
Li J, Butcher J, Mack D, Stintzi A. Functional impacts of the intestinal microbiome in the pathogenesis of inflammatory bowel disease  Inflamm Bowel Dis. 2015 Jan;21(1):139-53 PMID:25248007
 
Benchimol EI, Manuel DG, Guttmann A, Nguyen GC, Mojaverian N, Quach P, Mack DRChanging age demographics of inflammatory bowel disease in Ontario, Canada: a population-based cohort study of epidemiology trends. Inflamm Bowel Dis. 2014 Oct;20(10):1761-9 PMID:25159453
 
Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters TD, Aronow B, Xavier RJ, Gevers D, Denson LA. Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest. 2014 Aug;124(8):3617-33. doi: 10.1172/JCI75436. Epub 2014 Jul 8. Erratum in: J Clin Invest. 2015 Mar 2;125(3):1363. PMID:25003194
 
Sunseri W, Hyams JS, Lerer T, Mack DR, Griffiths AM, Otley AR, Rosh JR, Carvalho R, Grossman AB, Cabrera J, Pfefferkorn MD, Rick J, Leleiko NS, Hitch MC, Oliva-Hemker M, Saeed SA, Kappelman M, Markowitz J, Keljo DJ; Pediatric Inflammatory Bowel Disease Collaborative Research Group. Retrospective cohort study of methotrexate use in the treatment of pediatric Crohn's disease. Inflamm Bowel Dis. 2014 Aug;20(8):1341-5 PMID:24983976
 
Benchimol EI, Mack DR, Nguyen GC, Snapper SB, Li W, Mojaverian N, Quach P, Muise AM. Incidence, outcomes, and health services burden of very early onset inflammatory bowel disease. Gastroenterology. 2014 Oct;147(4):803-813.e7 PMID:24951840
 
Dhillon SS, Fattouh R, Elkadri A, Xu W, Murchie R, Walters T, Guo C, Mack D, Huynh HQ, Baksh S, Silverberg MS, Griffiths AM, Snapper SB, Brumell JH, Muise AM. Variants in nicotinamide adenine dinucleotide phosphate oxidase complex components determine susceptibility to very early onset inflammatory bowel disease. Gastroenterology. 2014 Sep;147(3):680-689 PMID:24931457
 
Goyal A, Hyams JS, Lerer T, Leleiko NS, Otley AR, Griffiths AM, Rosh JR, Cabrera JM, Oliva-Hemker MM, Mack DR, Rick JN, Pfefferkorn MD, Carvalho R, Grossman AB, Hitch MC, Sudel B, Kappelman MD, Saeed SA, Faubion WA, Schaefer ME, Markowitz JF, Keljo DJ; Pediatric Inflammatory Bowel Disease Collaborative Research Group. Liver enzyme elevations within 3 months of diagnosis of inflammatory bowel disease and likelihood of liver disease. J Pediatr Gastroenterol Nutr. 2014 Sep;59(3):321-3 PMID:24796799
 
Minar P, Haberman Y, Jurickova I, Wen T, Rothenberg ME, Kim MO, Saeed SA, Baldassano RN, Stephens M, Markowitz J, Rosh J, Crandall WV, Heyman MB, Mack DR, Griffiths AM, Baker SS, Hyams JS, Kugathasan S, Denson LA. Utility of neutrophil Fcγ receptor I (CD64) index as a biomarker for mucosal inflammation in pediatric Crohn's disease. Inflamm Bowel Dis. 2014 Jun;20(6):1037-48 PMID:24788216
 
Benchimol EI, Guttmann A, Mack DR, Nguyen GC, Marshall JK, Gregor JC, Wong J, Forster AJ, Manuel DG. Validation of international algorithms to identify adults with inflammatory bowel disease in health administrative data from Ontario, Canada.  J Clin Epidemiol. 2014 Aug;67(8):887-96 PMID:24774473
 
 
Gevers D, Kugathasan S, Denson LA, Vázquez-Baeza Y, Van Treuren W, Ren B, Schwager E, Knights D, Song SJ, Yassour M, Morgan XC, Kostic AD, Luo C, González A, McDonald D, Haberman Y, Walters T, Baker S, Rosh J, Stephens M, Heyman M, Markowitz J, Baldassano R, Griffiths A, Sylvester F, Mack D, Kim S, Crandall W, Hyams J, Huttenhower C, Knight R, Xavier RJ. The treatment-naive microbiome in new-onset Crohn's disease. Cell Host Microbe. 2014 Mar 12;15(3):382-92. doi: 10.1016/j.chom.2014.02.005. PMID:24629344
 
Dhillon SS, Mastropaolo LA, Murchie R, Griffiths C, Thöni C, Elkadri A, Xu W, Mack A, Walters T, Guo C, Mack D, Huynh H, Baksh S, Silverberg MS, Brumell JH, Snapper SB, Muise AM. Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel diseaseClin Transl Gastroenterol. 2014 Jan 16;5:e46. doi: 10.1038/ctg.2013.17. PMID:24430113
 
Costea I, Mack DR, Lemaitre RN, Israel D, Marcil V, Ahmad A, Amre DK. Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's diseaseGastroenterology. 2014 Apr;146(4):929-31. doi: 10.1053/j.gastro.2013.12.034. Epub 2014 Jan 7. PMID:24406470
 
Walters TD, Kim MO, Denson LA, Griffiths AM, Dubinsky M, Markowitz J, Baldassano R, Crandall W, Rosh J, Pfefferkorn M, Otley A, Heyman MB, LeLeiko N, Baker S, Guthery SL, Evans J, Ziring D, Kellermayer R, Stephens M, Mack D, Oliva-Hemker M, Patel AS, Kirschner B, Moulton D, Cohen S, Kim S, Liu C, Essers J, Kugathasan S, Hyams JS; PRO-KIIDS Research Group. Increased effectiveness of early therapy with anti-tumor necrosis factor-a vs an immunomodulator in children with Crohn's diseaseGastroenterology. 2014 Feb;146(2):383-91. doi: 10.1053/j.gastro.2013.10.027. Epub 2013 Oct 23. PMID:24162032
 
Aujnarain A, Mack DR, Benchimol EI. The role of the environment in the development of pediatric inflammatory bowel disease. Curr Gastroenterol Rep. 2013 Jun;15(6):326. doi: 10.1007/s11894-013-0326-4. Review. PMID: 23640032
 
Walters TD, Kim M, Denson LA, Griffiths AM, Dubinsky M, Markowitz J, Baldassano R, Crandall W, Rosh J, Pfefferkorn M, Otley A, Heyman MB, Leleiko N, Baker S, Guthery SL, Evans J, Ziring D, Kellermayer R, Stephens M, Mack D, Oliva-Hemker M, Patel AS, Kirschner B, Moulton D, Cohen S, Kim S, Liu C, Essers J, Kugathasan S, Hyams JS; PRO-KIIDS Research Group. Increased Effectiveness of Early Therapy With Anti-Tumor Necrosis Factor-α vs an Immunomodulator in Children With Crohn's Disease. Gastroenterology. 2013 Oct 23. pii: S0016-5085(13)01501-1. doi: 10.1053/j.gastro.2013.10.027. PMID: 24162032
 
Kumar V, Mack DR, Marcil V, Israel D, Krupoves A, Costea I, Lambrette P, Grimard G, Dong J, Seidman EG, Amre DK, Levy E. Genome-wide Association Study Signal at the 12q12 Locus for Crohn's Disease May Represent Associations with the MUC19 Gene Inflamm Bowel Dis. 2013 May;19(6):1254-1259. PMID: 23619718
 
Sheridan J, Mack DR, Amre DK, Israel DM, Cherkasov A, Li H, Grimard G, Steiner TS. A Non-Synonymous Coding Variant (L616F) in the TLR5 Gene Is Potentially Associated with Crohn's Disease and Influences Responses to Bacterial Flagellin. PLoS One. 2013 Apr 11;8(4):e61326. doi: 10.1371/journal.pone.0061326. Print 2013. PMID: 23593463 
 
Wine E, Mack DR, Hyams J, Otley AR, Markowitz J, Crandall WV, Leleiko N, Muise AM, Griffiths AM, Turner D. Interleukin-6 is associated with steroid resistance and reflects disease activity in severe pediatric ulcerative colitis. J Crohns Colitis. 2013 Jan 19. doi:pii: S1873-9946(12)00508-9. 10.1016/j.crohns.2012.12.012. [Epub ahead of print] PMID: 23339932  
 
Zeisler B, Lerer T, Markowitz J, Mack D, Griffiths A, Bousvaros A, Keljo D, Rosh J, Evans J, Kappelman M, Otley A, Kay M, Grossman A, Saeed S, Carvalho R, Oliva-Hemker M, Faubion W, Sudel B, Pfefferkorn M, Ashai-Khan F, Leleiko N, Hyams J; Pediatric Inflammatory Bowel Disease Collaborative Research Group. Outcome following aminosalicylate therapy in children newly diagnosed as having ulcerative colitis. J Pediatr Gastroenterol Nutr. 2013 Jan;56(1):12-8. doi: 10.1097/MPG.0b013e31826ac41a. 
 
Bertinato J, Simpson JR, Sherrard L, Taylor J, Plouffe LJ, Van Dyke D, Geleynse M, Dam YY, Murphy P, Knee C, Vresk L, Holland N, Quach H, Mack DR, Cooper M, L'abbé MR, Hayward S. Zinc supplementation does not alter sensitive biomarkers of copper status in healthy boys. J Nutr. 2013 Mar;143(3):284-9. doi: 10.3945/jn.112.171306. Epub 2013 Jan 9. PMID: 23303874 
 
Marcil V, Mack DR, Kumar V, Faure C, Carlson CS, Beaulieu P, Israel D, Krupoves A, Costea I, Lambrette P, Grimard G, Dong J, Seidman EG, Amre DK, Levy E. Association Between the PTPN2 Gene and Crohn's Disease: Dissection of Potential Causal Variants. Inflamm Bowel Dis. 2013 May;19(6):1149-1155.PMID: 23518806  
 
Michail S, Durbin M, Turner D, Griffiths AM, Mack DR, Hyams J, Leleiko N, Kenche H, Stolfi A, Wine E. Alterations in the gut microbiome of children with severe ulcerative colitis. Inflamm Bowel Dis. 2012 Oct;18(10):1799-808. doi: 10.1002/ibd.22860. Epub 2011 Dec 14. PMID: 22170749 
 
Otley A, LeLeiko N, Langton C, Lerer T, Mack D, Evans J, Pfefferkorn M, Carvalho R, Rosh J, Griffiths A, Oliva-Hemker M, Kay M, Bousvaros A, Stephens M, Samson C, Grossman A, Keljo D, Markowitz J, Hyams J; Pediatric IBD Collaborative Research Group. Budesonide use in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2012 Aug;55(2):200-4. doi: 10.1097/MPG.0b013e31824a09c2. PMID: 22258289 
 
Turner D, Griffiths AM, Walters TD, Seah T, Markowitz J, Pfefferkorn M, Keljo D, Waxman J, Otley A, LeLeiko NS, Mack D, Hyams J, Levine A. Mathematical weighting of the pediatric Crohn's disease activity index (PCDAI) and comparison with its other short versions. Inflamm Bowel Dis. 2012 Jan;18(1):55-62. doi: 10.1002/ibd.21649. Epub 2011 Feb 23. PMID: 21351206 
 
Krupoves A, Mack D, Seidman E, Deslandres C, Amre D. Associations between variants in the ABCB1 (MDR1) gene and corticosteroid dependence in children with Crohn's disease. Inflamm Bowel Dis. 2011 Nov;17(11):2308-17. doi: 10.1002/ibd.21608. Epub 2011 Jan 6. PMID: 21987299 
 
Siegel CA, Siegel LS, Hyams JS, Kugathasan S, Markowitz J, Rosh JR, Leleiko N, Mack DR, Crandall W, Evans J, Keljo DJ, Otley AR, Oliva-Hemker M, Farrior S, Langton CR, Wrobel IT, Wahbeh G, Quiros JA, Silber G, Bahar RJ, Sands BE, Dubinsky MC. Real-time tool to display the predicted disease course and treatment response for children with Crohn's disease. Inflamm Bowel Dis. 2011 Jan;17(1):30-8. doi: 10.1002/ibd.21386. Epub 2010 Sep 1. PMID: 20812335
 
Turner D, Mack DR, Hyams J, LeLeiko N, Otley A, Markowitz J, Kasirer Y, Muise A, Seow CH, Silverberg MS, Crandall W, Griffiths AM. C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) or both? A systematic evaluation in pediatric ulcerative colitis. J Crohns Colitis. 2011 Oct;5(5):423-9. doi: 10.1016/j.crohns.2011.05.003. Epub 2011 Jun 2. PMID: 21939916
 
Davis LD, Spencer WJ, Pham VT, Ward TL, Blais DR, Mack DR, Kaplan H, Altosaar I. (14)C radiolabeling of proteins to monitor biodistribution of ingested proteins. Anal Biochem. 2011 Mar 1;410(1):57-61. doi: 10.1016/j.ab.2010.11.028. Epub 2010 Nov 20. PMID: 21094630
 
Kempinska A, Benchimol EI, Mack A, Barkey J, Boland M, Mack DR. Short-course ondansetron for the prevention of methotrexate-induced nausea in children with Crohn disease. J Pediatr Gastroenterol Nutr. 2011 Oct;53(4):389-93. doi: 10.1097/MPG.0b013e31822855e7. PMID: 21681112  
 
Sylvester FA, Turner D, Draghi A 2nd, Uuosoe K, McLernon R, Koproske K, Mack DR, Crandall WV, Hyams JS, Leleiko NS, Griffiths AM. Fecal osteoprotegerin may guide the introduction of second-line therapy in hospitalized children with ulcerative colitis. Inflamm Bowel Dis. 2011 Aug;17(8):1726-30. doi: 10.1002/ibd.21561. Epub 2010 Dec 3. PMID: 21744427
 
Krupoves A, Mack D, Deslandres C, Seidman E, Amre DK. Variation in the glucocorticoid receptor gene (NR3C1) may be associated with corticosteroid dependency and resistance in children with Crohn's disease. Inflamm Bowel Dis. 2011 Nov;17(11):2308-17. doi: 10.1002/ibd.21608. Epub 2011 Jan 6. PMID: 21987299 
 
 Hyams JS, Lerer T, Mack DR, Bousvaros A, et al for the Pediatric Inflammatory Bowel Disease Collaborative Research Group Registry. Outcome Following Thiopurine Use in Children with Ulcerative Colitis: A Prospective Multicenter Study. Am J Gastroenterol 2011;106:981-987. PMID: 21224840
 
Dykstra NS, Hyde L, Adawi D, Kulik D, Ahrne S, Molin G, Jeppsson B, Mackenzie A, Mack DR. Pulse probiotic administration induces repeated small intestinal Muc3 expression in rats. Pediatr Res. 2011 Mar;69(3):206-11. doi: 10.1203/PDR.0b013e3182096ff0. PMID: 21135754
 
Krupoves A, Mack DR, Seidman EG, Deslandres C, Bucionis V, Amre DK. Immediate and long-term outcomes of corticosteroid therapy in pediatric Crohn's disease patients. Inflamm Bowel Dis. 2011 Apr;17(4):954-62. doi: 10.1002/ibd.21415. PMID: 20684012 
Dykstra N, Hyde L, Mackenzie A, Mack DR. Lactobacillus plantarum 299v prevents caspase-dependent apoptosis in vitro. Probiotics and Antimicrobial Peptides 2011;3:21-26.

Beauchamp JN, Gaboury I, Ni A, Boland MP, Mack DR. Solid-food introduction in infants diagnosed as having a cow's-milk protein-induced enterocolitis. J Pediatr Gastroenterol Nutr. 2011 May;52(5):639-43. doi: 10.1097/MPG.0b013e318207ef1a. PMID: 21464755

Krupoves A, Mack D, Deslandres C, Seidman E, Amre DK. Variation in the glucocorticoid receptor gene (NR3C1) may be associated with corticosteroid dependency and resistance in children with Crohn's disease. Pharmacogenet Genomics. 2011 Aug;21(8):454-60. doi: 10.1097/FPC.0b013e3283476a01. PMID: 21633323

Tsampalieros A, Griffiths AM, Barrowman N, Mack DR. Use of C-reactive protein in children with newly diagnosed inflammatory bowel disease. J Pediatr. 2011 Aug;159(2):340-2. doi: 10.1016/j.jpeds.2011.04.028. Epub 2011 Jun 8. PMID: 21645909
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