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Leanne Ward photo of Leanne Ward
Senior Scientist, CHEO Research Institute
MD FRCPC FAAP
Research Chair in Pediatric Bone Health, University of Ottawa
Associate Professor, Faculty of Medicine, University of Ottawa
Director, Pediatric Bone Health Clinical and Research Programs, CHEO

lward@cheo.on.ca
613-737-7600 Ext. 2253
Research Practice Areas:
Current Research:

Dr. Ward leads local, national and global research initiatives in the study of mechanisms, epidemiology and treatment of bone disorders in children, with an emphasis on osteoporosis in children with serious chronic illnesses. To date, musculoskeletal health has been studied in children with leukemia, rheumatic disorders, nephrotic syndrome, Duchenne muscular dystrophy, and inflammatory bowel disease. The main goal of the research program is to develop improved diagnostic and monitoring tools as well as treatment strategies for children with bone fragility due to osteoporosis. Dr. Ward’s areas of interest also extend to rickets (acquired and congenital) and skeletal dysplasias (such as osteogenesis imperfecta).

 
Research Team:
  • Steve Anderson
  • Heather Cosgrove
  • Victor Konji
  • Josie MacLennan
  • Maya Scharke
  • Liz Sykes
  • Monica Tomiak
Biography:

Dr. Leanne Ward is an Associate Professor of Pediatrics (Faculties of Medicine and Surgery at the University of Ottawa), the Director of the Pediatric Bone Health Clinical and Research Programs, and the Principal Investigator of a Canada-wide research program evaluating the effect of glucocorticoids on bone health in children with leukemia, rheumatic conditions and nephrotic syndrome (called the STeroid-associated Osteoporosis in the Pediatric Population (STOPP) research program). She has received a number of awards for her work on the effects of chronic childhood illnesses on the developing skeleton, including the Canadian Child Health Clinician Scientist Career Development Award, the Canadian Institutes for Health Research New Investigator Award, the Canadian Child Health Clinician Scientist Career Enhancement Award and most recently, a University of Ottawa Research Chair Award.

Sample Publications:
Huber AM and Ward LM. The Impact of Underlying Disease on the Skeletal Phenotype of Children with Rheumatic Disorders: A Review of Current Literature. Seminars in Arthritis and Rheumatism, 46(1):49–63, 2016.

Ward LM, Konji VN, Ma J. Invited review. The Management of Osteoporosis in Children. Osteoporosis International, 27(7):2147–2179, 2016.

Jefferson A, Leonard H, Siafarikas A, Woodhead H, Fyfe S, Ward LM, Munns C, Motil C, Tarquinio D, Shapiro JR, Brismar T, Ben-Zeev B, Bisgaard A-M, Coppola G, Ellaway C, Freilinger M, Geerts S, Humphreys P, Jones M, Lane J, Larsson G, Lotan M, Percy A, Pineda M, Skinner S, Syhler B, Thompson S, Weiss B, Engerström I W, Downs J. Clinical Guidelines for Management of Bone Health in Rett Syndrome Based on Expert Consensus and Available Evidence. PLOS ONE, 11(2):e0146824, 2016.

Ward LM, Bardai G, Moffat P, Al-Jallad H, Trejo P, Glorieux FH and Rauch F. Osteogenesis Imperfecta Type VI in Individuals from Northern Canada. Calcified Tissue International, 98(6): 566-572, 2016.

Misof BM, Roschger P, McMillan H, Ma J. Klaushofer K, Rauch F and Ward LM. Histomorphometry and bone matrix mineralization before and after bisphosphonate treatment in boys with Duchenne muscular dystrophy: a paired trans-iliac biopsy study. Journal of Bone and Mineral Research, 31(5): 1060-9, 2016. 

Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, Dimeglio L, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P, Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W. Global Consensus Recommendations on Prevention and Management of Nutritional Rickets. Journal of Clinical Endocrinology and Metabolism, 101(2): 394-415, 2016

Bardai G, Lemyre E, Moffatt P, Palomo T, Glorieux FH, Tung J, Ward LM, Rauch F. Osteogenesis Imperfecta Type I Caused by COL1A1 Deletions. Calcified Tissue International. 98(1): 76-84, 2016.

Hogler W, Ward LM. Osteoporosis in Children with Chronic Disease. Endocr Dev. 28:176-95, 2015

Cummings EA, Ma J, Fernandez CV, Halton J, Alos N, Miettunen PM, Jaremko JL, Ho J, Shenouda N, Matzinger MA, Lentle B, Stephure D, Stein R, Sbrocchi AM, Rodd C, Lang B, Israels S, Grant RM, Couch R, Barr R, Hay J, Rauch F, Siminoski K, Ward LM and the Canadian STOPP Consortium. Incident Vertebral Fractures in Children with Leukemia During the Four Years Following Diagnosis. Journal of Clinical Endocrinology and Metabolism, 100 (9):3408-17, 2015 

Leblanc CM A, Ma J, Taljaard M, Roth J, Scuccimarri R, Miettunen P, Lang B, Huber AM, Houghton K, Jaremko J L, Ho J, Shenouda N, Matzinger M, Lentle B, Stein R, Sbrocchi AM, Oen K, Rodd C, Jurencak R, Cummings EA, Couch R, Cabral DA. Atkinson S, Alos N, Rauch F, Siminoski K, Ward LM and the Canadian STOPP Consortium. Incident Vertebral Fractures and Risk Factors in the First Three Years Following Glucocorticoid Initiation Among Pediatric Patients With Rheumatic Disorders. Journal of Bone and Mineral Research, 30(9):1667-75, 2015

Ma J, Siminoski K, Alos N, Halton J, Ho J, Lentle B, Matzinger M, Shenouda N, Atkinson S, Barr R, Cabral DA, Couch R, Cummings EA, Fernandez CV, Grant RM, Rodd C, Sbrocchi AM, Scharke M, Rauch F, Ward LM, on behalf of the Canadian STOPP Consortium. The Choice of Normative Pediatric Reference Database Changes Spine Bone Mineral Density Z-Scores But Not the Relationship Between Bone Mineral Density and Prevalent Vertebral Fractures. Journal of Clinical Endocrinology & Metabolism, 100: 1018–1027, 2015.

Jaremko JL, Siminoski K, Firth G, Matzinger M, Shenouda N, Konji VN, Roth J, Sbrocchi AM, Reed M, O’Brien K, Nadel H, McKillop S, Kloiber R, Dubois J, Coblentz C, Charron M, Ward LM, and the Canadian STOPP Consortium. Common normal variants of pediatric vertebral development that mimic fractures: a pictorial review from a national longitudinal bone health study. Pediatric Radiology, 45(4):593-605, 2015.
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