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Kusum Menon
Senior Scientist, CHEO Research Institute
Physician, Division of Critical Care, CHEO
Associate Professor, Departments of Pediatrics and Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa

menon@cheo.on.ca
613-737-7600 Ext. 2538
Research Practice Areas:
Current Research:

Dr. Menon’s research includes a series of studies on adrenal insufficiency and septic shock – this is a large multi-stage research project aimed at studying the role of steroids in pediatric critical illness and shock. Work to date has included defining the problem in a large critically ill patient population, surveying clinicians’ perceptions of the problem, conducting a systematic review of the existing literature, and the completion of a pilot randomized controlled trial of steroids versus a placebo in pediatric shock. The final goal of this program is to help clinicians develop a consistent approach to the use of steroids in children with fluid and vasoactive infusion-dependent shock. Presently, Dr. Menon is the lead investigator on a multi-hospital international phase III/IV randomized controlled clinical trial of steroids versus a placebo in pediatric septic shock (the SHIPSS study). This study is based on the results from the phase II pilot study (STRIPES study).

In addition to her interest in adrenal insufficiency and septic shock, Dr. Menon is interested in the consent process in research, specifically in the critical care environment. This research program is aimed at exploring the consent process in pediatric critical care research, in order to identify and work through existing barriers. Currently Dr. Menon is supervising a student-led study that is exploring parental understanding of consent forms in the PICU.

 
Research Team:
Biography:
Dr. Menon is a Senior Scientist at the CHEO Research Institute, and an Associate Professor in the Departments of Pediatrics and Epidemiology and Community Medicine at the University of Ottawa. She has a Master’s degree in Epidemiology and has won numerous awards for research and research mentorship. She is also a member of the Executive of Canadian Critical Care Trials Group, an internationally recognized critical care research network with over 120 high impact peer-reviewed publications. She has recently completed two Canadian Institutes of Health Research-funded multi-centre trials in pediatric critical care, which have resulted in two high-impact publications. Dr. Menon was the recipient of the CHEO Outstanding Investigator Award in 2013. Recently, she was appointed to a Tier 2 University Research Chair with the University of Ottawa.
Sample Publications:

Woodger O, Menon K, Yazbeck M, Acharya A. A Pragmatic Method for Identification of Long-Stay Patients in the PICU. Hosp Pediatr. 2018 Oct;8(10):636-642.

Lamontagne F, D'Aragon F, Burns KEA, Belley-Côté É, Kho M, Menon K, Duan E, Masse MH, Archambault P, Hrymak C, Rochwerg B. Canadian Critical Care Society revised process for guideline development and endorsement. Can J Anaesth. 2018 Oct;65(10):1163-1164

O'Hearn KJ, Martin DA, Dagenais M, Menon K. Ability to Assent in Pediatric Critical Care Research: A Prospective Environmental Scan of Two Canadian PICUs. Pediatr Crit Care Med. 2018 Aug;19(8):e438-e441.

McIntyre L, Taljaard M, McArdle T, Fox-Robichaud A, English SW, Martin C, Marshall J, Menon K, Muscedere J, Cook DJ, Weijer C, Saginur R, Maybee A, Iyengar A, Forster A, Graham ID, Hawken S, McCartney C, Seely AJ, Stiell IG, Thavorn K, Fergusson DA. FLUID trial: a protocol for a hospital-wide open-label cluster crossover pragmatic comparative effectiveness randomised pilot trial. BMJ Open. 2018 Aug 23;8(8):e022780

Tucci M, Lacroix J, Fergusson D, Doctor A, Hébert P, Berg RA, Caro J, Josephson CD, Leteurtre S, Menon K, Schechtman K, Steiner ME, Turgeon AF, Clayton L, Bockelmann T, Spinella PC; Canadian Critical Care Trials Group; Pediatric Critical Care Blood Research Network (BloodNet); Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. The age of blood in pediatric intensive care units (ABC PICU): study protocol for a randomized controlled trial. Trials. 2018 Jul 28;19(1):404.

Menon K, McNally JD. Corticosteroids in Pediatric Septic Shock Are Helpful. Crit Care Med. 2018 Apr;46(4):635-636.

B, Oczkowski S, Siemieniuk RA, Menon K, Szczeklik W, English S, Agoritsas T, Belley-Cote E, D'Aragon F, Alhazzani W, Duan E, Gossack-Keenan K, Sevransky J, Vandvik P, Venkatesh B, Guyatt G, Annane D. Corticosteroids in sepsis: an updated systematic review and meta-analysis (protocol). BMJ Open. 2017 Jun 30;7(6):e016847.

Menon K, McNally JD, Zimmerman J, Agus M, O’Hearn K, Watson S, Wong HR, Duffett M, Wypij D, Choong K. Primary Outcome Measures in Pediatric Septic Shock Trials: A Systematic Review. Pediatr Crit Care Med 2017;18(11):e146-154.

Liu A, Menon K. Contributions of a survey and retrospective cohort study to the planning of a randomised controlled trial of corticosteroids in the treatment of paediatric septic shock. Trials. 2018 May 21;19(1):283.

Menon K, McNally D, Acharya A, O'Hearn K, Choong K, Wong HR, McIntyre L, Lawson M. Random serum free cortisol and total cortisol measurements in pediatric septic shock. Canadian Critical Care Trials Group. J Pediatr Endocrinol Metab. 2018 Jul 26;31(7):757-762.

Rochwerg B, Oczkowski SJ, Siemieniuk RAC, Agoritsas T, Belley-Cote E, D'Aragon F, Duan E, English S, Gossack-Keenan K, Alghuroba M, Szczeklik W, Menon K, Alhazzani W, Sevransky J, Vandvik PO, Annane D, Guyatt G. Corticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis. Crit Care Med. 2018 Sep;46(9):1411-1420.

Menon K, McNally JD, O’Hearn K, Acharya A, Wong HR, Lawson M, Ramsay T, McIntyre L, Gilfoyle E, Tucci M, Wensley D, Gottesman R, Morrison G, Choong K. A delayed consent model in a randomized trial of corticosteroids in pediatric septic shock. Pediatr Crit Care Med. Volume 18, Issue 11 (2017), Page 1009-1018.

Duffett M, Choong K, Foster J, Meade M, Menon K, Parker M, Cook D. High-quality randomized controlled trials in pediatric critical care: A survey of barriers and facilitators. Pediatr Crit Care Med. Volume 18, Issue 5 (2017), Page 405-413.

Menon K, McNally JD, O’Hearn K, Wong H, Lawson M, Acharya A, Ramsay T, McIntyre L, Gilfoyle E, Wensely D, Tucci M, Gottesman R, Morrison G, Choong K. A Randomized controlled trial of Hydrocortisone in Pediatric Septic Shock: A pilot feasibility trial. Pediatr Crit Care Med. Volume 18, Issue 6 (2017), Page 505-512.

Menon K, McNally D, O’Hearn K, Zimmerman J, Agus, M, Wong H, Wypij D, Choong K. Primary Outcome Measures in Pediatric Septic Shock Trials: A Systematic Review. Pediatr Crit Care Med. Volume 18, Issue 3 (2017), Page e146-e154.

Van Beinum A, Hornby L, Dhanani S, Evans J, Ward R, Menon K. Feasibility of conducting prospective, observational research on critically ill, dying patients in the intensive care unit. J Med Ethics. Volume 43, Issue 1 (2017), Page 47-51.

O’Hearn K, McNally JD, Choong K, Acharya A, Wong HR, Lawson M, Ramsay T, McIntyre L, Gilfoyle E, Tucci M, Wensley D, Gottesman R, Morrison G, Menon K for the Canadian Critical Care Trials Group. Steroids in Fluid and/or Vasoactive Infusion Dependent Pediatric Shock: a Study Protocol for a Randomized Controlled Trial. Trials. Volume 6, Issue 17 (2016), Page 238.

Garde A, O’Hearn K, Nicholls S, Menon K. Reporting of consent rates in critical care studies: room for improvement. J Clin Epidemiol. Volume 74, Issue 51 (2016), Page 51-6.

McNally JD, Menon K, Lawson ML, Williams K, Doherty DR. 1,25 dihydroxyvitamin D levels in PICU: risk factors and association with clinical course. J Clin Endocrinol Metab. 2015 Jun 8. [Epub ahead of print].

Sampaio T, O’Hearn K, Reddy D, Menon K. The influence of fluid overload on the length of mechanical ventilation in pediatric congenital heart surgery. Pediatr Cardiol. 2015 Jun 30. [Epub ahead of print].

Menon K, Wong, HR. Corticosteroids in Pediatric Shock-A Call to Arms. Accepted to Pediatric Critical Care Medicine.

Duffett M, Choong K, Hartling L, Menon K, Thabane L, Cook DJ. Pilot randomized trials in pediatric critical care: A systematic review. Pediatr Crit Care Med. 2015 Jun 26. [Epub ahead of print]

Menon K, McNally D, Choong K, Lawson M, Ramsay T, Wong H. A cohort study of pediatric shock: frequency of corticosteroid use and association with clinical outcomes. Shock. 2015 Feb 13. [Epub ahead of print].

Menon K, Dundon B, Twolan BL, AlShamari S. Unplanned Extubations in a Pediatric Intensive Care Unit. Accepted for publication to Dynamics.

McNally J, Iliriani K, Pojsupap S, Sampson M, O’Hearn K, McIntyre L, Fergusson D, Menon K. Rapid Normalization of Vitamin D Levels: A Meta-Analysis. Pediatrics 2015 Jan;135(1):e152-e166.

Pojsupap S, Iliriani K, Sampson M, O’Hearn K, McIntyre L, Fergusson D, Menon K, McNally J. Efficacy of high-dose vitamin D in pediatric asthma: A systematic review and meta-analysis. J Asthma. 2014 Nov 3:1-29.

Duffet M, Choong K, Meade M, Menon K, Foster J, Cheng J, Cook DJ. Clonidine in the sedation of mechanically ventilated children: a pilot randomized trial. J Crit Care. 2014 Oct;29(5):758-63.

Gunz A, Dhanani S, Whyte H, Menon K, Foster J, Parker M, McNally JD. Identifying significant and relevant events during pediatric transport: A modified Delphi study. Pediatr Crit Care Med. 2014 Sep;15(7):653-9.

Choong K, Fraser D, Joffe A, Hutchison J, Menon K, Foster G, Pullenayegum E, Jouvet P, Ward R. Acute Rehabilitation Practices in Critically Ill Children: A multi-centre study. Pediatr Crit Care Med. 2014 Jul;15(6):e270-9.

Menon K, Ward R. A Study of Consent for Participation in a Non-Therapeutic Study in the Pediatric Intensive Care Population. J Med Ethics 2014 Feb;40(2):123-6.

Duffett M, Choong K, Hartling L, Menon K, Thabane L, Cook DJ. Randomized controlled trials in pediatric critical care: a scoping review. Crit Care 2013 Oct 29;17(5).

Menon K. Use of hydrocortisone for refractory shock in children. Crit Care Med. Oct 2013, 41(10).

Thomas, M. & Menon, K. (2013). Consenting to pediatric critical care research: Understanding the perspective of parents. Dynamics, 24(3), 18-25.

Menon K, McNally D, Choong K, Sampson M. A systematic review and meta-analysis on the effect of steroids in pediatric shock. Ped Crit Care Med. Volume 14, Issue 5 (2013), Page 474-480.

Menon K, McNally JD, Choong K, Ward RE, Lawson ML, Ramsay T, Wong HR. A survey of stated physician practices and beliefs on the use of steroids in pediatric fluid and/or vasoactive infusion-dependent shock. Ped Crit Care Med. Volume 14, Issue 5 (2013), Page 462-466.

McNally JD, Doherty DR, Lawson ML, Al-Dirbashi OY, Chakraborty P, Ramsay T, Menon K. The relationship between vitamin d status and adrenal insufficiency in critically ill children. J Clin Endocrinol Metab. Volume 98, Issue 5 (2013), Page E877-881.

McNally JD, Menon K, Chakraborty P, Fisher L, Williams KA, Al-Dirbashi OY, Girolamo T, Maharajh G, Doherty DR. Impact of Anesthesia and Surgery for Congenital Heart Disease on the Vitamin D Status of Infants and Children: A Prospective Longitudinal Study. Anesthesiology. Volume 119, Issue 1 (2013), Page 71-80.

Menon K, Ward R; for the Canadian Critical Care Trials Group. A study of consent for participation in a non-therapeutic study in the pediatric intensive care population. J Med Ethics. Epub ahead of print (Jan 2013).

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