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Alex Mackenzie photo of Alex Mackenzie
Senior Scientist, Apoptosis Research Centre,
CHEO Research Institute
Physician, Division of Endocrinology, CHEO
Professor, Department of Pediatrics, Faculty of Medicine,
University of Ottawa
Research Practice Areas:
Current Research:
Dr. MacKenzie and his team are developing a strategic toolbox and preclinical research pathway for inherited disorders and orphan diseases. The lab has identified gene subsets for three disorders – Duchenne Muscular Dystrophy, Myotonic Dystrophy, and Spinal Muscular Atrophy – and the goal is to broaden the research to include other genetic disorders.
Research Team:
Dr. Alex MacKenzie is a principal investigator at the CHEO Research Institute and a Professor in the Department of Medicine at the University of Ottawa. He is a specialist in the field of Spinal Muscular Atrophy, where he has published extensively in the areas of molecular genetics of pediatric disease.
Sample Publications:
Farooq, F., F.A. Molina, J. Hadwen, D. Mackenzie, L, Witherspoon, M. Osmond, M. Holcik and A.E. MacKenzie (2011). Prolactin increases SMN expression and survival in a severe SMA mouse model via STAT5 pathway. Journal of Clinical Investigation, 121:3042-50.
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