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Alex Mackenzie photo of Alex Mackenzie
Senior Scientist, CHEO Research Institute
Physician, Division of Endocrinology, CHEO
Professor, Department of Pediatrics, Faculty of Medicine,
University of Ottawa
Research Practice Areas:
Current Research:
Dr. MacKenzie and his team are developing a strategic toolbox and preclinical research pathway for inherited disorders and orphan diseases. The lab has identified gene subsets for three disorders – Duchenne Muscular Dystrophy, Myotonic Dystrophy, and Spinal Muscular Atrophy – and the goal is to broaden the research to include other genetic disorders.
Research Team:
Dr. Alex MacKenzie is a principal investigator at the CHEO Research Institute and a Professor in the Department of Medicine at the University of Ottawa. He is a specialist in the field of Spinal Muscular Atrophy, where he has published extensively in the areas of molecular genetics of pediatric disease.
Sample Publications:
Farooq, F., F.A. Molina, J. Hadwen, D. Mackenzie, L, Witherspoon, M. Osmond, M. Holcik and A.E. MacKenzie (2011). Prolactin increases SMN expression and survival in a severe SMA mouse model via STAT5 pathway. Journal of Clinical Investigation, 121:3042-50.
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