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Robert Korneluk, Ph.D., FRSC photo of Robert Korneluk
Senior Scientist, CHEO Research Institute
Distinguished Professor, Departments of Biochemistry, Microbiology and Immunology, and Pediatrics, Faculty of Medicine, University of Ottawa
Director, Apoptosis Research Centre (ARC), CHEO Research Institute
Head, Solange Gauthier Karsh Molecular Genetics Laboratory
(CHEO Research Institute)
Scientific Co-founder of Aegera Therapeutics Inc. (Montreal)
Howard Hughes Medical Institute International Research Scholar, for three terms
(1997-2001)

bob@arc.cheo.ca
613-738-3281
Research Practice Areas:
Current Research:

Dr. Korneluk and his team are investigating the role of the Inhibitor of Apoptosis (IAP) gene family in the regulation of programmed cell death, also known as apoptosis. His group is investigating the role of the IAPs – in particular, XIAP, cIAP1 and cIAP2 – in the progression of cancer, and is exploring the use of small molecule IAP antagonists for cancer treatment. A particular focus is on the use of the small molecule antagonists to enhance cancer treatment. Dr. Korneluk is also investigating the roles of the IAPs in muscle biology and disease. These studies will add insight into normal and disease processes involved in myogenesis and muscle repair in wasting syndromes such as muscular dystrophy, atrophy and cancer-induced cachexia.

Research Team:
  • Shawn Beug
  • Sandy Boehmer
  • Janelle Chabot
  • Nathalie Earl
  • Cristin Healy
  • Lynn Kelly
  • Eric LaCasse
  • Stephaine Pichette
  • Tarun Sanda
  • Martine St.Jean
  • Danielle Walker
Biography:
Dr. Robert G. Korneluk is Professor, Departments of Pediatrics and Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa. He is also the scientific director of the Apoptosis Research Centre at CHEO and a Distinguished Professor of the University of Ottawa. Dr. Korneluk is an International Research Scholar of the Howard Hughes Medical Institute and a Fellow of the Royal Society of Canada, and has received the prestigious McLaughlin Medal from the Society. His laboratory studies fundamental aspects of apoptosis, an intrinsic mechanism by which a cell initiates a genetic process to commit programmed cell death.
Sample Publications:
Bueg, S.T., D.P. Conrad, T. Alain., R.G Korneluk, and E.C. LaCasse (2015). Combinational cancer immunotherapy strategies with proapoptotic small-molecule IAP antagonists. Int J Dev Bio 59: 141-47.

LaCasse, E.C., S.T. Beug and R.G. Korneluk (2015). The inhibitors of apoptosis (IAPs): over 20 years of research into life and death. Semin Cell Dev Biol, 39:70-1.
 
Faye, M.D., S. Beug, T.E. Graber, N. Earl, X. Xiang, B. Wild, S. Langlois, J. Michaud, K.N. Cowan, R.G. Korneluk and M. Holcik (2014). IGF2BP1 controls cell death and drug resistance in rhabdomyosarcomas by regulating translation of cIAP1. Oncogene, April 7:doi:10.

Beug, S.T., E.C. LaCasse, and R.G. Korneluk (2014). Smac mimetics combined with innate immune stimuli create the perfect cytokine storm to kill tumor cells. Oncoimmunology 3, e28541.
 
Beug, S.T., V.A. Tang, E.C. LaCasse, H.H. Cheung, C.E. Beauregard, J Brun, J.P. Nuyens, N. Earl, M. St-Jean, J. Holbrook, H. Dastidar, D.J. Mahoney, C. Ilkow, F. Le Boeuf, J.C. Bell and R.G. Korneluk (2014). Smac mimetics and innate immune stimuli synergize to promote tumor death. Nature Biotechnology, 32:182-90.
 
Enwere, E.K., N. Adam, E.C. LaCasse and R.G. Korneluk (2014). Role of the TWEAK-Fn14-cIAP1-NF-kB signaling axis in the regulation of myogenesis and muscle homeostasis. Frontiers in Immunology Review, 5:34.
 
Enwere, E., L. Boudreault, J. Holbrook, K. Timusk, N. Earl, E. LaCasse, J-M. Renaud and R.G. Korneluk (2013). Loss of cIAP1 attenuates soleus muscle pathology and improves diaphragm function in mdx mice. Human Molecular Genetics, 22:867-78.
 
Emwere, E., T.K. Timusk, J. Holbrook, J. Vineham, R.L. Mrad, B. Sivaraj, M. Issac, D. Uehling, R. Al-Awar, E. LaCasse, and R.G. Korneluk (2012). TWEAK and cIAP1 regulate myoblast fusion through the non-canonical NF-kB signaling. Science Signaling, 5:ra75.
 
McComb, S., H.H Cheung, R.G. Korneluk, S. Wang, L. Krishnan and S. Sad (2012). cIAP2 and cIAP2 Limit Macrophage Necroptosis by Inhibiting RIP1 and RIP3 Activation. Cell Death Differ, 19:1791-801.
 
Beug, S.T., H.H. Cheung, E.C. LaCasse, R.G. Korneluk (2012) Modulation of immune signaling by the IAPs. Trends Immunol, Trends in Immunology, 33:535-45.
 
Cheung, H.H., M. St. Jean, S.T. Beug, R. Lejmi Mrad, E. LaCasse, S.D. Baird, D.F. Stojdl, R.A. Screaton, and R.G. Korneluk (2011). SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds. Cell Death Dis 14: 2e146.
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