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Nicole Le Saux
Clinical Investigator, CHEO Research Institute
Physician, Division of Infectious Disease, CHEO
Associate Professor, Department of Pediatrics, Faculty of Medicine,
University of Ottawa
Research Practice Areas:
Current Research:
Dr. Le Saux’s current research areas are efficacy of vaccines, including vaccine uptake, and surveillance for vaccine-preventable diseases. Vaccines of interest include rotavirus, influenza, and more recently the immunogenicity of maternally administered pertussis vaccine. Currently, surveillance activities on the effect of rotavirus vaccine on the epidemiology of rotavirus hospitalizations and emergency department visits in Canada are underway. As an active member of IMPACT, Dr. Le Saux is also involved in other targets such as the epidemiology of meningococcal disease, and vaccine preventable diseases. Other goals for the coming year in the area of research include the epidemiology of pediatric Clostridium difficile, and antimicrobial use and stewardship in hospitals.
Research Team:
  • Chantal Bergeron
  • Jennifer Bowes
  • Judy Dennis
Dr. Le Saux is a Clinical Investigator at the Children’s Hospital of Eastern Ontario (CHEO) Research Institute Associate Professor, Faculty of Medicine, University of Ottawa. She is an infectious diseases physician at CHEO where she is currently Medical Director of Infection Prevention and Control. She is Royal College- certified in internal medicine, infectious diseases and anatomic pathology. She is also an active member of the examination board in Infectious Diseases at the Royal College of Physicians and Surgeons. Dr. Le Saux serves on many committees, including the Canadian Pediatric Society Infectious Diseases subcommittee and the Provincial Infectious Diseases Advisory Committee on Immunizations (PIDAC-I) of Ontario. She has published extensively in the areas of vaccines and clinical infectious diseases issues.
Sample Publications:
Le Saux N, Bettinger J, Déry P, Embree J, Vaudry W, Halperin H, McDermid A, Booth TF, Coyle D. The Hidden Costs and Characteristics of Childhood Rotavirus Emergency Visits in Canada Pediatric Infectious Diseases Journal 2011;31(2):159-163.

Le Saux N, Bettinger J, Halperin S, Vaudry W, Scheifele D. Hospital acquired rotavirus infections: burden in Canadian hospitals. J Infect Prevention 2011;12(4);159-162.

Costiniuk CT, Le Saux N, Sell E, Doja A, Karnauchow T, Jacob P, Hui C. Miller Fisher syndrome in a toddler with influenza A (pH1N1) infection. J Child Neurol. 2011 Mar; (3):385-8

Le Saux N, Bettinger J, Vaudry W, Scheifele D, Halperin S. Substantial morbidity for hospitalized children with community acquired rotavirus infections. Pediatric Infectious Diseases Journal 2010;29(9): 879-82.

Le Saux N, Bettinger J, Wootton S, Halperin S, Vaudry W, Scheifele D, Tsang R. Profile of Serogroup Y Meningococcal Infections in Canada: Implications for Vaccine Selection Can J Infec Dis Med Microbiol 2009 20(4):e130-e134.

Somech R, Lai YH, Grunebaum E, Le Saux N, Cutz E, Roifman C. Polyethylene glycol modified adenosine deaminase impoved lung disease but not liver disease in partial ADA deficiency. Journal of Allergy and Clinical Immunology 2009 Oct;124(4):848-50. Epub 2009 Aug 8.

Gaboury I, Coyle D, Le Saux N, Economic analysis of AOM. Pediatr Child Health 2010;15(7):e14-18.
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