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Pranesh Chakraborty photo of Pranesh Chakraborty
Director, Newborn Screening Ontario
Physician, Section of Metabolism and Newborn Screening,
Department of Pediatrics, CHEO
Medical Director, BORN Ontario
Associate Professor, Department of Pediatrics, Faculty of Medicine,
University of Ottawa (cross appointed to Department of BMI and to Pathology and Laboratory Medicine)
613-737-7600 Ext. 3437
Research Practice Areas:
Current Research:
Dr. Chakraborty has three current areas of research interest:
  1. Development and evaluation of novel laboratory assays for diagnosis and screening of inborn errors of metabolism.
  2. Clinical and health services research on outcomes of children with inborn errors of metabolism.
  3. Basic translation research on inborn errors of mitochondrial tRNA metabolism.
Research Team:
  • Larry Fisher
  • Hapsatou Mamady
  • Nathan McIntosh
  • Mylene Theriault
Dr. Chakraborty is a physician certified by the Royal College in Medical Biochemistry and Pediatrics, with a subspecialty in Biochemical Genetics. He joined CHEO in 2003 as a clinician seeing patients with Inborn Errors of Metabolism (IEM). In 2006 he led the transition of Ontario’s newborn screening program to Ottawa leading to the establishment of Newborn Screening Ontario (NSO) at CHEO. In 2008 he was instrumental in the founding of the Better Outcomes Registry and Network (BORN Ontario) at CHEO as a prescribed registry in Ontario. Finally, he is a Principal Investigator for the Canadian Inherited Metabolic Disease Research Network which recently was awarded a $1.5M CIHR Emerging Teams grant for rare disease research. Throughout his career, he has been involved in clinical and translational research related to IEM.
Sample Publications:
Potter BK, Little J, Chakraborty P., Kronick JB, Evans J, Frei J, Sutherland SC, Wilson K, Wilson BJ. “Variability in the clinical management of fatty acid oxidation disorders: results of a survey of Canadian metabolic physicians.”, J Inherit Metab Dis. 2011 Jun 1. [Epub ahead of print]

Wilson K, Hawken S, Potter BK, Chakraborty P., Kwong J, Crowcroft N, Rothwell D, Manuel D., “Patterns of emergency room visits, admissions and death following recommended pediatric vaccinations-A population based study of 969,519 vaccination events.”, Vaccine. 2011 May 12;29(21):3746-52. Epub 2011 Apr 8.

Al-Dirbashi OY, Kölker S, Ng D, Fisher L, Rupar T, Lepage N, Rashed MS, Santa T, Goodman SI, Geraghty MT, Zschocke J, Christensen E, Hoffmann GF, Chakraborty P., “Diagnosis of glutaric aciduria type 1 by measuring 3-hydroxyglutaric acid in dried urine spots by liquid chromatography tandem mass spectrometry.”, J Inherit Metab Dis. 2011 Feb;34(1):173-80. Epub 2010 Oct 27.

Kennedy S, Potter BK, Wilson K, Fisher L, Geraghty M, Milburn J, Chakraborty P., “The first three years of screening for medium chain acyl-CoA dehydrogenase deficiency (MCADD) by Newborn Screening Ontario.”., BMC Pediatr. 2010 Nov 17;10:82.

Wilson, Kennedy, Potter, Geraghty, Chakraborty P., “Developing a National Newborn Screening Strategy for Canada,” Health Law Review. 2010 March; 18(2):p31-9

Al-Dirbashi OY, Fisher L, McRoberts C, Siriwardena K, Geraghty M, Chakraborty P., “Identification of a neonate with hepatorenal tyrosinemia by combined routine newborn screening for succinylacetone, acylcarnitines and amino acids.” Clinical Biochemistry 2010 May;43(7-8):691-3.

Wilson K, Potter B, Manuel D, Keelan J, Chakraborty P., “Revisiting the possibility of serious adverse events from the whole cell pertussis vaccine: Were metabolically vulnerable children at risk?”, Med Hypotheses, Aug 4. 2010 Jan;74(1):150-4

Miller FA, Hayeems RZ, Bombard Y, Little J, Carroll JC, Wilson B, Allanson J, Paynter M, Bytautas JP, Christensen R, Chakraborty P., “Clinical obligations and public health programmes: healthcare provider reasoning about managing the incidental results of newborn screening.” J Med Ethics. 2009 Oct;35(10):626-34. 
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