The VIPS (Vascular Effects of
Infection in Pediatric Stroke) study is a large multicenter study funded by the National Institutes of Health (NIH) and co-led by two researchers in pediatric stroke at SickKids in Toronto
(Dr. Gabrielle DeVeber) and the University of California in San Francisco (Dr. Heather Fullerton). Dr. Peter Humphreys is the CHEO-based site investigator.
The purpose of the
VIPS study is to assess the possible role of intercurrent infections in the
pathogenesis of pediatric stroke. The study was closed to accrual two
years ago but the data is still being analyzed (August 2016). CHEO was
able to contribute 12 participants to the VIPS study.
So far, there have been 4
publications as a result
of this study, and we expect more to follow.
Wei, Felix, Diedrich, K, Fullerton H, DeVeber G, Wintermark M, Hodge J,
Kirton A. Arterial Tortuosity: An Imaging Biomarker of Childhood Stroke
Pathogenesis? Stroke 2016 May
- Elkind M, Hills
N, Glaser C, Lo W, Amlie-Lefond C, Dlamini N, Kneen R, Hod EA, Wintermark M,
deVeber G, Fullerton H. Herpesvirus infections and childhood ischemic
stroke: Results of the VIPS Study. Circulation. 2016 January 26. PMID:
- Wintermark M,
Hills NK, DeVeber GA, et al. Arteriopathy diagnosis in childhood
arterial ischemic stroke: results of the
vascular effects of infection in pediatric stroke study. Stroke. 2014 December;
- Fullerton H,
Elkind M, Barkovich A, Glaser C, Gidden D, Hills N, Leiva-Salinas C, Wintermark
M, deVeber G. The vascular effects of infection in pediatric stroke (VIPS)
study. Journal of Child Neurology 2011 May; 1101-110. PMID:21616922.