| |
Dr. Robert Screaton’s Group -
Selected Publications
Fu, A., Ng, A. C-H., Depatie, C.,
Wijesekara, N., He, Y. Wang, G-S., Bardeesy, N., Scott, F.W.,
Touyz, R.M., Wheeler, M.B, and Screaton, R.A.
Loss of Lkb1 in adult β cells
increases β
cell mass and enhances glucose tolerance in mice. Cell Metabolism 10: 285-95
(2009).
Press Release
Lerner, R.G., Depatie, C., Rutter, G.A., Screaton, R.A.,
Balthasar, N. A role for the CREB coactivator CRTC2 in the
hypothalamic mechanisms linking glucose-sensing with gene
regulation. EMBO Reports 10: 1175-81 (2009).
Goh, S-L, Looi, Y.,
Fang, J., Shen, H., Bodner, C. Houle, M., Ng, A. C-H.,
Screaton, R.A.,* and Featherstone, M*.
Transcriptional activation by Meis1A in response to PKA
signalling requires the TORC family of CREB
co-activators. JBC, 284, 18904-12 (2009).
*corresponding authors.
Fu, A. and
Screaton, R.A.
Using Kinomics to Delineate Signaling
Pathways: Control of CRTC2/TORC2 by the AMPK Family. Cell Cycle,
7: 3823-28 (2009).
Jansson, D., Cheuk-Him Ng, A., Fu, A., Depatie, C., Al Azzabi,
M, and Screaton, R.A.
Glucose controls CREB
activity in islet cells via regulated phosphorylation of TORC2.
PNAS
105: 10161-10166 (2008).
Qi, L., Heredia, J., Altarejos, J.Y., Screaton, R.,
Goebel, N., Niessen, S., MacLeod, I.X., Liew, C.W., Kulkarni,
R., Bain, J., Newgard, C., Nelson, M., Evans, R.M., Yates, J.,
and Montminy, M. TRB3 links the E3 ubiquitin ligase COP1 to
lipid metabolism. Science 312: 1763-66 (2006).
Koo, S-H, Flechner, L.,
Qi, L., Zhang, X., Screaton, R.A., Jeffries, S., Hedrick,
S., Xu, W., Boussouar, F., Brindle, P., Takemori, H., and
Montminy, M. The CREB coactivator TORC2 is a key regulator of
fasting glucose metabolism. Nature 437:1109-11 (2005).
Screaton R.A.,
Conkright, M.D., Katoh, Y., Best, J., Canettieri, G., Jeffries,
S., Guzman, E., Niessen,
S., Yates, J.R. III, Takemori, H., Okamoto, M., Montminy,
M..The CREB Coactivator TORC2 Functions as a Calcium
and cAMP Sensitive Coincidence Detector. Cell 119: 61-74 (2004).
Conkright, M.D., Canettieri, G., Screaton, R., Guzman,
E., Miraglia, L., Hogenesch, J., Montminy, M. TORCs: Novel
Transducers of Regulated CREB Activity. Mol. Cell 12: 413-23
(2003).
Jhala, U., Canettieri, G., Screaton, R.A., Kulkarni,
R.N., Krajewski, S., Reed, J., Walker, J., Lin, X., White, M.,
and Montminy, M. cAMP Promotes Pancreatic Beta Cell Survival via
CREB Mediated Induction of IRS2. Genes Dev. 15: 1575-1580
(2003).
Screaton, R.A.,
Kiessling, S., Sansom, O., Millar, C., Maddison, K., Bird, A.,
Clarke, A., and Frisch, S.M. Fas-associated death domain protein
interacts with methyl-CpG binding domain protein 4: A potential
link between genome surveillance and apoptosis. PNAS 100:
5211-5216 (2003).
Screaton, R.A.,
DeMarte, L., Draber, P, and Stanners, C.P. The specificity for
the differentiation blocking activity of carcinoembryonic
antigen (CEA) resides in its glycophosphatidyl-inositol (GPI)
anchor. J. Cell. Biol. 150: 613-626 (2000).
Screaton, R.A.,
Penn, L.Z., and Stanners, C.P. Carcinoembryonic antigen, a human
tumor marker, cooperates with Myc and Bcl-2 in cellular
transformation. J. Cell. Biol. 137: 939-952 (1997).
|
